"SERPINE1" Related Products

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Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, NBD-tagged

Cat. No. : SERPINE1-5492H
Product Overview : Recombinant human SERPINE1 NBDlabeled mutant contains a Ser to Cys replacement around the vitronectinbinding site. Incorporation of an NBD label allows for the reporting ofbinding to vitronectin.
Description : SERPINE1is a protein that in humans is encoded by the SERPINE1 gene. SERPINE1 is aserine protease inhibitor (serpin) that functions as the principal inhibitorof tissue plasminogen activator (tPA) and urokinase (uPA), the activators ofplasminogen and hence fibrinolysis (the physiological breakdown of bloodclots). It is a serine protease inhibitor (serpin) protein.
Source : E. coli
Species : Human
Form : Frozenliquid in 0.05 M sodium phosphate + 0.1 M NaCl + 1 mM EDTA, pH 6.6.
Concentration : 2.5 mg/ml
Molecular Weight : 43.0 kDa
Storage : Store inworking aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : SERPINE1
PAI-1 in complexwith the SMB domain of Vitronectin PDB 1OC0. :

Gene Name : SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1 [ Homo sapiens ]
Synonyms : SERPINE1; serpin peptidase inhibitor, cladeE (nexin, plasminogen activator inhibitor type 1), member 1; Plasminogen activator inhibitor 1; Endothelialplasminogen activator inhibitor; PAIE; Clade E; PLANH1; SERPINE 1; PAI;PAI-1; PAI1; plasminogen activator inhibitor-1; plasminogen activatorinhibitor, type I; serine (or cysteine) proteinase inhibitor, clade E (nexin,plasminogen activator inhibitor type 1), member 1; Endothelial plasminogenactivator inhibitor
Gene ID : 5054
mRNA Refseq : NM_000602
Protein Refseq : NP_000593
MIM : 173360
UniProt ID : P05121
Chromosome Location : 7q21.3-q22
Pathway : Adipogenesis; BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade; Chagas disease(American trypanosomiasis); Circadian Clock; Complement and CoagulationCascades; Direct p53 effectors; Dissolution of Fibrin Clot; E2F transcriptionfactor network; HIF-1-alpha transcription factor network; HIF-2-alphatranscription factor network; Hemostasis; Platelet activation; Plateletdegranulation; Regulation of nuclear SMAD2/3 signaling
Function : peptidase inhibitor activity;protease binding; protein binding; serine-type endopeptidase inhibitoractivity; contributes to receptor binding

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