Recombinant Human Serpin Peptidase Inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), Member 1, Non-LRP-tagged

• Cat.No.: SERPINE1-5496H
• Product Overview: Recombinanthuman SERPINE1 non-LRP binding stable mutant with a substitution of GlutamicAcid for Arginine at position 76 that greatly decreases the binding of thismutant to the low density lipoprotein receptor-related protein (LRP). Theputative LRP binding exosite is thought to overlap with the heparin bindingsite on the SERPINE1 molecule. Binding to LRP or similar receptors leads tothe clearance of SERPINE1 complexes.

Specification

• Species: Human
• Source: E.coli
• Description: SERPINE1is a protein that in humans is encoded by the SERPINE1 gene. SERPINE1 is aserine protease inhibitor (serpin) that functions as the principal inhibitorof tissue plasminogen activator (tPA) and urokinase (uPA), the activators ofplasminogen and hence fibrinolysis (the physiological breakdown of bloodclots). It is a serine protease inhibitor (serpin) protein.
• Form: Frozenliquid in 0.05 M sodium phosphate + 0.1 M NaCl + 1 mM EDTA, pH 6.6.
• Concentration: 2.5 mg/ml
• Molecular Weight: 43.0 kDa
• Storage: Store inworking aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: SERPINE1

Gene Information

• Gene Name: SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1 [ Homo sapiens ]
• Synonyms: SERPINE1; serpin peptidase inhibitor, cladeE (nexin, plasminogen activator inhibitor type 1), member 1; Plasminogen activator inhibitor 1; Endothelialplasminogen activator inhibitor; PAIE; Clade E; PLANH1; SERPINE 1; PAI;PAI-1; PAI1; plasminogen activator inhibitor-1; plasminogen activatorinhibitor, type I; serine (or cysteine) proteinase inhibitor, clade E (nexin,plasminogen activator inhibitor type 1), member 1; Endothelial plasminogenactivator inhibitor
• Gene ID: 5054
• mRNA Refseq: NM_000602
• Protein Refseq: NP_000593
• MIM: 173360
• UniProt ID: P05121
• Chromosome Location: 7q21.3-q22
• Pathway: Adipogenesis; BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade; Chagas disease(American trypanosomiasis); Circadian Clock; Complement and CoagulationCascades; Direct p53 effectors; Dissolution of Fibrin Clot; E2F transcriptionfactor network; HIF-1-alpha transcription factor network; HIF-2-alphatranscription factor network; Hemostasis; Platelet activation; Plateletdegranulation; Regulation of nuclear SMAD2/3 signaling
• Function: peptidase inhibitor activity;protease binding; protein binding; serine-type endopeptidase inhibitoractivity; contributes to receptor binding