Expand| Cat. No. : | SERPINE1-5499H |
| Product Overview : | Wild type SERPINE1 cloned with a cysteine residue at the N-terminus, supplied inbuffer with 1 mM DTT to prevent dimerization. |
| Description : | SERPINE1is a protein that in humans is encoded by the SERPINE1 gene. SERPINE1 is aserine protease inhibitor (serpin) that functions as the principal inhibitorof tissue plasminogen activator (tPA) and urokinase (uPA), the activators ofplasminogen and hence fibrinolysis (the physiological breakdown of bloodclots). It is a serine protease inhibitor (serpin) protein. |
| Source : | E. coli |
| Species : | Human |
| Form : | Frozenliquid in 0.05 M sodium phosphate + 0.1 M NaCl + 1 mM EDTA + 1 mM DDT, pH 6.6. |
| Concentration : | 2.5 mg/ml |
| Molecular Weight : | 43.0 kDa |
| Purity : | > 95% |
| Biological Activity : | > 98% active as determined bytitration with HWM tc-urokinase and SDS-PAGE. |
| Storage : | Store inworking aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
| OfficialSymbol : | SERPINE1 |
| PAI-1 in complexwith the SMB domain of Vitronectin PDB 1OC0. : |
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| Gene Name : | SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1 [ Homo sapiens ] |
| Synonyms : | SERPINE1; serpin peptidase inhibitor, cladeE (nexin, plasminogen activator inhibitor type 1), member 1; Plasminogen activator inhibitor 1; Endothelialplasminogen activator inhibitor; PAIE; Clade E; PLANH1; SERPINE 1; PAI;PAI-1; PAI1; plasminogen activator inhibitor-1; plasminogen activatorinhibitor, type I; serine (or cysteine) proteinase inhibitor, clade E (nexin,plasminogen activator inhibitor type 1), member 1; Endothelial plasminogenactivator inhibitor |
| Gene ID : | 5054 |
| mRNA Refseq : | NM_000602 |
| Protein Refseq : | NP_000593 |
| MIM : | 173360 |
| UniProt ID : | P05121 |
| Chromosome Location : | 7q21.3-q22 |
| Pathway : | Adipogenesis; BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade; Chagas disease(American trypanosomiasis); Circadian Clock; Complement and CoagulationCascades; Direct p53 effectors; Dissolution of Fibrin Clot; E2F transcriptionfactor network; HIF-1-alpha transcription factor network; HIF-2-alphatranscription factor network; Hemostasis; Platelet activation; Plateletdegranulation; Regulation of nuclear SMAD2/3 signaling |
| Function : | peptidase inhibitor activity;protease binding; protein binding; serine-type endopeptidase inhibitoractivity; contributes to receptor binding |
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