Recombinant Human Transforming Growth Factor, Beta Receptor 1

• Cat.No.: TGFBR1-5523H
• Product Overview: Recombinant Human TGFBR1is derived from human SMAD3 (215-230) and is suitable for use as thesubstrate for TGFBR1 superfamily.

Specification

• Cat. No.: TGFBR1-5523H
• Description: The protein encodedby this gene forms a heteromeric complex with type II TGF-beta receptors whenbound to TGF-beta, transducing the TGF-beta signal from the cell surface tothe cytoplasm. The encoded protein is a serine/threonine protein kinase.Mutations in this gene have been associated with Loeys-Dietz aortic aneurysmsyndrome (LDAS).
• Source: Sf9 insect cells
• Species: Human
• Form: Lyophilized
• Purity: 95.79% by HPLCanalysis
• Molecular Weight: CRT194 Da
• Amino Acid Sequence: KKKVLTQMGSPSIRC-S(pS)VS
• Applications: Peptide Substrate.The peptide can be used as a substrate for the following active proteinkinases: ALK1, ALK2, and ALK4.
• Reconstitution: Dilute peptide in 20mM Tris-HCl, pH 7.5 tp a final concentration of 1 mg/ml.
• Storage: Store product at-20°C. Stable for 1 year from date of shipment. For optimal storage, aliquotdiluted product into smaller quantities and store at -20°C. Avoid repeatedfreezethaw cycles.
• OfficialSymbol: TGFBR1
• Pathways: ALK1 signalingevents; Adherens junction; Chagas disease (American trypanosomiasis); Chronicmyeloid leukemia; Colorectal cancer; Cytokine-cytokine receptor interaction;Endocytosis; Glypican 1 network; HTLV-I infection; MAPK signaling pathway;Osteoclast differentiation; Pancreatic cancer; Pathways in cancer; SignalTransduction; Signaling by TGF beta; TGF Beta Signaling Pathway; TGF-betasignaling pathway

Gene Information

• Gene Name: TGFBR1 transforming growthfactor, beta receptor 1 [ Homo sapiens ]
• Synonyms: TGFBR1;transforming growth factor, beta receptor 1; AAT5; ALK5; MSSE; SKR4; ALK-5;LDS1A; LDS2A; TGFR-1; ACVRLK4; TGF-beta receptor type-1; tbetaR-I;OTTHUMP00000021783; OTTHUMP00000242324; OTTHUMP00000242325;OTTHUMP00000242326; OTTHUMP00000242329; TGF-beta receptor type I; TGF-betatype I receptor; activin receptor-like kinase 5; transforming growth factorbeta receptor I; serine/threonine-protein kinase receptor R4; activin Areceptor type II-like kinase, 53kD; activin A receptor type II-like kinase,53kDa; transforming growth factor-beta receptor type I; activin A receptortype II-like protein kinase of 53kD; transforming growth factor, betareceptor I (activin A receptor type II-like kinase, 53kD); EC 2.7.11.30; Activin A receptor type II-like protein kinase of 53kD; Activinreceptor-like kinase 5; Serine/threonine-protein kinase receptor R4;Transforming growth factor-beta receptor type I
• Gene ID: 7046
• mRNA Refseq: NM_001130916
• Protein Refseq: NP_001124388
• MIM: 190181
• UniProt ID: P36897
• Chromosome Location: 9q22
• Function: ATP binding; I-SMADbinding; SMAD binding; contributes to growth factor binding; metal ionbinding; nucleotide binding; protein binding; protein heterodimerizationactivity; protein serine/threonine kinase activity; receptor activity;transforming growth factor beta binding; contributes to transforming growthfactor beta binding; transforming growth factor beta binding; transforminggrowth factor beta-activated receptor activity; contributes to transforminggrowth factor beta-activated receptor activity