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Recombinant Human Tumor Necrosis Factor

Cat.No. : TNF-378H
Product Overview : Recombinant human TNFalpha is expressed in human 293 cells and has been shown by gel filtration tobe predominantly a non-covalently linked homotrimer, with a molecular mass of51 kDa.
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Cat. No. : TNF-378H
Description : Tumor necrosisfactor-alpha is the best-known member of this class, and sometimes referredto when the term tumor necrosis factor is used. TNF is a monocyte-derivedcytotoxin that has been implicated in tumour regression, septic shock andcachexia.
Source : HEK 293 cells
Species : Human
Purity : >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel wasstained with Coomassie blue.
Molecular Mass : 17 kDa,non-disulfided bonded homotrimer, glycosylate.
Endotoxin Level : Endotoxin Free <1EU/μg
Biological Activity : 0.05 to 0.5 ng/mL ED50
Specific Activity : The specificactivity was determined by the dose-dependent cytotoxity of the TNF alphasensitive cell line L-929 in the presence of Actinomycin D.
OfficialSymbol : TNF
Pathways : Adipocytokinesignaling pathway; Adipogenesis; African trypanosomiasis; Allograftrejection; Alzheimer" s disease; Amoebiasis; Amyotrophic lateral sclerosis(ALS); Angiopoietin receptor Tie2-mediated signaling; Antigen processing andpresentation; Apoptosis; Asthma; Calcineurin-regulated NFAT-dependenttranscription in lymphocytes; Canonical NF-kappaB pathway; Caspase cascade inapoptosis; Cellular roles of Anthrax toxin; Ceramide signaling pathway
Gene Name : TNF tumor necrosis factor [ Homosapiens ]
Synonyms : TNF;tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin;APC1 protein; OTTHUMP00000029281; TNF, monocyte-derived; TNF,macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha;tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member2; Tumornecrosis factor; Cachectin
Gene ID : 7124
mRNA Refseq : NM_000594
Protein Refseq : NP_000585
MIM : 191160
UniProt ID : P01375
Chromosome Location : 6p21.3
Function : cytokine activity; identicalprotein binding; protease binding; protein binding; transcription regulatoryregion DNA binding; tumor necrosis factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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