Recombinant Human Tumor Necrosis Factor

Cat. No. : TNF-378H
Product Overview : Recombinant human TNFalpha is expressed in human 293 cells and has been shown by gel filtration tobe predominantly a non-covalently linked homotrimer, with a molecular mass of51 kDa.
Description : Tumor necrosisfactor-alpha is the best-known member of this class, and sometimes referredto when the term tumor necrosis factor is used. TNF is a monocyte-derivedcytotoxin that has been implicated in tumour regression, septic shock andcachexia.
Source : HEK 293 cells
Species : Human
Purity : >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel wasstained with Coomassie blue.
Molecular Mass : 17 kDa,non-disulfided bonded homotrimer, glycosylate.
Endotoxin Level : Endotoxin Free <1EU/μg
Biological Activity : 0.05 to 0.5 ng/mL ED50
Specific Activity : The specificactivity was determined by the dose-dependent cytotoxity of the TNF alphasensitive cell line L-929 in the presence of Actinomycin D.
OfficialSymbol : TNF
Pathways : Adipocytokinesignaling pathway; Adipogenesis; African trypanosomiasis; Allograftrejection; Alzheimer" s disease; Amoebiasis; Amyotrophic lateral sclerosis(ALS); Angiopoietin receptor Tie2-mediated signaling; Antigen processing andpresentation; Apoptosis; Asthma; Calcineurin-regulated NFAT-dependenttranscription in lymphocytes; Canonical NF-kappaB pathway; Caspase cascade inapoptosis; Cellular roles of Anthrax toxin; Ceramide signaling pathway
PDB structure 2TNF. :

Gene Name : TNF tumor necrosis factor [ Homosapiens ]
Synonyms : TNF;tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin;APC1 protein; OTTHUMP00000029281; TNF, monocyte-derived; TNF,macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha;tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member2; Tumornecrosis factor; Cachectin
Gene ID : 7124
mRNA Refseq : NM_000594
Protein Refseq : NP_000585
MIM : 191160
UniProt ID : P01375
Chromosome Location : 6p21.3
Function : cytokine activity; identicalprotein binding; protease binding; protein binding; transcription regulatoryregion DNA binding; tumor necrosis factor receptor binding

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