Recombinant Human Tumor Necrosis Factor, His-tagged

Cat. No. : TNF-379H
Product Overview : Recombinant HumanTNF-a His produced in E. coli is a single, non-glycosylated, polypeptidechain containing 157 amino acids fragment (77-233) and having a MW 21.85 kDawith an amino-terminal hexahistidine tag.
Description : Tumor necrosisfactor-alpha is the best-known member of this class, and sometimes referredto when the term tumor necrosis factor is used. TNF is a monocyte-derivedcytotoxin that has been implicated in tumour regression, septic shock andcachexia.
Source : E. coli
Species : Human
Form : Recombinant humanTNF-a-His (0.75 mg/ml) is supplied in 10 mM Tris + 0.1M NaCl + 50% glycerol.
Purity : Greater than 95.0%as determined by analysis by RP-HPLC and by SDS-PAGE.
Storage : Store at 2-4°C ifentire vial will be used within 2-4 weeks. Store, frozen at -20°C for longerperiods of time. Please avoid freeze-thaw cycles.
OfficialSymbol : TNF
Pathways : Adipocytokinesignaling pathway; Adipogenesis; African trypanosomiasis; Allograftrejection; Alzheimer" s disease; Amoebiasis; Amyotrophic lateral sclerosis(ALS); Angiopoietin receptor Tie2-mediated signaling; Antigen processing andpresentation; Apoptosis; Asthma; Calcineurin-regulated NFAT-dependenttranscription in lymphocytes; Canonical NF-kappaB pathway; Caspase cascade inapoptosis; Cellular roles of Anthrax toxin; Ceramide signaling pathway
PDB structure 2TNF. :

Gene Name : TNF tumor necrosis factor [ Homosapiens ]
Synonyms : TNF;tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha; TNF-a; cachectin;APC1 protein; OTTHUMP00000029281; TNF, monocyte-derived; TNF,macrophage-derived; TNF superfamily, member 2; tumor necrosis factor alpha;tumor necrosis factor-alpha; tumor necrosis factor ligand superfamily member2; Tumornecrosis factor; Cachectin
Gene ID : 7124
mRNA Refseq : NM_000594
Protein Refseq : NP_000585
MIM : 191160
UniProt ID : P01375
Chromosome Location : 6p21.3
Function : cytokine activity; identicalprotein binding; protease binding; protein binding; transcription regulatoryregion DNA binding; tumor necrosis factor receptor binding

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