"Vegfc" Related Products


Recombinant Mouse Vascular Endothelial Growth Factor C

Cat. No. : Vegfc-5535M
Product Overview : Recombinant mouse Vegfcis a 129 amino acid recombinant protein that lacks the N-terminal andC-terminal extensions and contains only the middle third VEGF homologydomain.
Description : Vascularendothelial growth factor C is a VEGF. The human gene encoding it is Vegfc.The protein encoded by this gene is a member of the platelet-derived growthfactor/vascular endothelial growth factor family, is active in angiogenesis,lymphangiogenesis and endothelial cell growth and survival, and can alsoaffect the permeability of blood vessels.
Source : E. coli
Species : Mouse
Form : Lyophilized fromacetic solution with 50 μg BSA per 1 μg Vegfc.
Purity : > 90% as determinedby SDS-PAGE analysis.
Molecular Weight : 18 kDa
Endotoxin Level : < 0.1 ng/μg of Vegfc
Biological Activity : Activity of Vegfcwill be tested by the stimulation of VEGFR3 phosphorylation in cellstransfected with VEGFR3. The expected ED50 is > 200 ng/ml.
Reconstitution : Centrifuge vialprior to opening. Add 0.1% acetic acid to the vial to fully solubilize theprotein to a concentration of 0.1-1.0 mg/ml. After complete solubilization ofthe protein, it can be further diluted to other aqueous solutions.
Storage : Store lyophilizedprotein at -20°C and reconstituted protein in working aliquots at -80°C.Avoid repeated freeze-thaw cycles.
OfficialSymbol : Vegfc
Pathways : Bladder cancer; Cytokine-cytokinereceptor interaction; Focal Adhesion; Focal adhesion; Hemostasis; PI3K/Akt/mTORsignaling pathway; Pancreatic cancer; Pathways in cancer; Platelet activation;Platelet degranulation; Renal cell carcinoma; Response to elevated plateletcytosolic Ca2+; Signal Transduction; Signaling by VEGF; VEGF bindsto VEGFR leading to receptor dimerization
Rendering based onPDB 2X1W. :

Gene Name : Vegfc vascular endothelialgrowth factor C [ Mus musculus ]
Synonyms : Vegfc;vascular endothelial growth factor C; VEGF-C; AW228853; vascularendothelial growth factor C; VRP; flt4-L; flt4 ligand; vascular endothelialgrowth factor C isoform 129; vascular endothelial growth factor C isoform 184;vascular endothelial growth factor-related protein; Vascular endothelial growth factor C; Flt4 ligand; Vascular endothelial growth factor-related protein
Gene ID : 22341
mRNA Refseq : NM_009506
Protein Refseq : NP_033532
UniProt ID : P97953
Chromosome Location : 8; 8 B3
Function : chemoattractantactivity; growth factor activity; vascular endothelial growth factor receptor3 binding

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