"Vegfc" Related Products

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Recombinant Rat Vascular Endothelial Growth Factor C

Cat. No. : Vegfc-5536R
Product Overview : Recombinant Rat Vegfc152S is a point mutant generated by the replacement of the second conservedCys residue of the recombinant processed Vegfc by a Ser residue.
Description : Vegfc, also knownas Vascular Endothelial Growth Factor Related Protein (VRP), is a recentlydiscovered VEGF growth factor family member that is most closely related toVEGF-D. The rat Vegfc cDNA encodes a pre-pro-protein of 416 amino acidsresidues.
Source : Insect cells
Species : Rat
Form : lyophilized
Purity : > 90%, bySDS-PAGE and visualized by silver stain.
Molecular Weight : 36-48 kDa
Range : 100-400 ng/ml
Endotoxin Level : < 0.1 ng per μgof Vegfc152S
Biological Activity : 5 x 103units/mg. Measured by its ability to stimulate phosphorylation of theVEGFR-3/FLT-4 receptor in porcine aortic endothelial cells (PAE/FLT-4 cells).The ED50 for this effect is typically 150-300 ng/ml.
Stabilizer : BSA
Reconstitution : Centrifuge vialbriefly before opening to bring contents to bottom of vial. The lyophilized Vegfc152Sis soluble in water and most aqueous buffers. The lyophilized Vegfc152Sshould be reconstituted in PBS or medium to a concentration not lower than 50μg/ml.
Storage : Lyophilized samplesare stable for greater than six months at -20°C to -70°C. Reconstituted Vegfc152Sshould be stored in working aliquots at -20°C. Avoid repeated freeze-thawcycles.
OfficialSymbol : Vegfc
Pathways : Bladder cancer; Cytokine-cytokinereceptor interaction; Focal Adhesion; Focal adhesion; Hemostasis; Pancreaticcancer; Pathways in cancer; Platelet activation; Platelet degranulation; Renalcell carcinoma; Response to elevated platelet cytosolic Ca2+; SignalTransduction; Signaling by VEGF; VEGF binds to VEGFR leading to receptordimerization; mTOR signaling pathway
Rendering based onPDB 2X1W. :

Gene Name : Vegfc vascular endothelialgrowth factor C [ Rattus norvegicus ]
Synonyms : Vegfc;vascular endothelial growth factor C; VRP; VEGF-C; flt4-L;flt4 ligand; vascular endothelial growth factor-related protein; Vascular endothelial growth factor C; Flt4 ligand; Vascular endothelial growth factor-related protein
Gene ID : 114111
mRNA Refseq : NM_053653
Protein Refseq : NP_446105
UniProt ID : O35757
Chromosome Location : 16p11
Function : chemoattractantactivity; growth factor activity; vascular endothelial growth factor receptor3 binding

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