| Cat. No. : |
SERPINE1-5502H |
| Product Overview : |
Recombinant activehuman SERPINE1, fluorescein labeled by iodoacetamide substitution at theN-terminal cysteine. |
| Description : |
SERPINE1 also knownas endothelial plasminogen activator inhibitor or serpin E1 is a protein thatin humans is encoded by the SERPINE1 gene. SERPINE1 is a serine protease inhibitor(serpin) that functions as the principal inhibitor of tissue plasminogenactivator (tPA) and urokinase (uPA), the activators of plasminogen and hencefibrinolysis (the physiological breakdown of blood clots). It is a serineprotease inhibitor (serpin) protein (SERPINE1). The other PAI, plasminogenactivator inhibitor-2 (PAI-2) is secreted by the placenta and only present insignificant amounts during pregnancy. In addition, protease nexin acts as aninhibitor of tPA and urokinase. PAI-1, however, is the main inhibitor of theplasminogen activators. |
| Source : |
E. coli |
| Species : |
Human |
| Molecule Weight : |
43.0 kDa |
| Form : |
Frozen liquid in0.05 M sodium phosphate + 0.1 M NaCl + 1 mM EDTA, pH 6.6. |
| Concentration : |
2.5 mg/ml |
| Storage : |
Storein working aliquots at -80°C, protected from light. Avoid repeatedfreeze-thaw cycles. |
| OfficialSymbol : |
SERPINE1 |
| Pathways : |
Adipogenesis;BMAL1:CLOCK/NPAS2 Activates Gene Expression; Blood Clotting Cascade;Complement and Coagulation Cascades; Dissolution of Fibrin Clot; E2Ftranscription factor network; HIF-2-alpha transcription factor network;Platelet activation; Platelet degranulation; Regulation of nuclear SMAD2/3signaling; Response to elevated platelet cytosolic Ca2+; Selenium Pathway;Senescence and Autophagy; TGF Beta Signaling Pathway; p53 signaling pathway |
