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Recombinant Human GCA grancalcin, EF-hand Calcium Binding Protein, His-tagged

Cat. No.: GCA-2921H
Product Overview: Recombinant Human GCA protein was expressed in E.coli with His-tag at the N-terminus. The molecular weight is 24010 Da(217 aa).
Description: Grancalcin is a protein that in humans is encoded by the GCA gene. grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
Sequences of amino acids: 1-217 aa
Formulation: 10 mM Tris. pH 8.0. 0.002% NaN3. 3mM NaCl. 2.5mM Imidazole.
Purity: 95%
Gene Name: GCA grancalcin, EF-hand calcium binding protein [ Homo sapiens ]
Synonyms: GCL; grancalcin; OTTHUMP00000204639; OTTHUMP00000204640; grancalcin, penta-EF-hand protein; grancalcin, EF-hand calcium-binding protein
Gene ID: 25801
mRNA Refseq: NM_012198
Protein Refseq: NP_036330
MIM: 607030
UniProt ID: P28676
Chromosome Location: 2q37.1
Pathway: Insulin signaling pathway; mTOR signaling pathway
Function: calcium ion binding; protein homodimerization activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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