Recombinant Human TEK Tyrosine Kinase, Endothelial, His-tagged
Cat.No. : | TEK-390H |
Product Overview : | Recombinant human TEK(a.a. 771-end) with N-terminal His tag, MW=45 kDa, expressed in an Baculovirusinfected Sf9 cell expression system. |
- Specification
- Gene Information
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Cat. No. : | TEK-390H |
Description : | The TEK receptortyrosine kinase is expressed almost exclusively in endothelial cells in mice,rats, and humans. This receptor possesses a unique extracellular domaincontaining 2 immunoglobulin-like loops separated by 3 epidermal growth factor-likerepeats that are connected to 3 fibronectin type III-like repeats. The ligandfor the receptor is angiopoietin-1. Defects in TEK are associated withinherited venous malformations; the TEK signaling pathway appears to becritical for endothelial cell-smooth muscle cell communication in venousmorphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. |
Source : | Baculovirus infectedSf9 cells |
Species : | Human |
Molecule Weight : | 45 kDa |
Form : | 25 mM Tris-HCl, pH8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT. |
Purity : | Greater than 90% bySDS-PAGE |
Specific Activity : | 140 U/µg. One unitis defined as the amount of enzyme that will phosphorylate 1 pmol of Tyrsubstrate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 3mM MgCl2, 3 mM MnCl2, 1 mM DTT, 3 µM Na-orthovanadate, 0.5 mM ATP, 30 µg/mlPoly (Glu:Tyr) 4:1 substrate, and 2 µg/ml recombinant Tie2. |
Applications : | usefulfor the study of enzyme kinetics, screening inhibitors, and selectivityprofiling. |
Storage : | >6 months at –80°C. |
OfficialSymbol : | TEK |
Pathways : | Angiogenesis;Angiopoietin receptor Tie2-mediated signaling; Cell surface interactions atthe vascular wall; Hemostasis; Rheumatoid arthritis; Tie2 Signaling |
Gene Name : | TEK TEK tyrosine kinase,endothelial [ Homo sapiens ] |
Synonyms : | TEK; TEK tyrosinekinase, endothelial; TIE2; VMCM; TIE-2; VMCM1; CD202B; angiopoietin-1receptor; hTIE2; p140 TEK; OTTHUMP00000021167; OTTHUMP00000227067; OTTHUMP00000227068;OTTHUMP00000227069; soluble TIE2 variant 1; soluble TIE2 variant 2;tyrosine-protein kinase receptor TEK; tunica interna endothelial cell kinase;tyrosine-protein kinase receptor TIE-2; EC 2.7.10.1 |
Gene ID : | 7010 |
mRNA Refseq : | NM_000459 |
Protein Refseq : | NP_000450 |
MIM : | 600221 |
UniProt ID : | Q02763 |
Chromosome Location : | 9p21 |
Function : | ATP binding;nucleotide binding; protein binding; protein kinase activity; proteintyrosine kinase activity; receptor activity; transmembrane receptor proteintyrosine kinase activity |
Products Types
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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