Human CCR5 peptide

• Cat.No.: CCR5-366H
• Product Overview: CCR5 peptide is used for blocking the activity of Anti-CCR5

Specification

• Description: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene.
• Species: Human
• Form: Liquid in PBS, pH 7.2 (10 mM NaH2PO4 + 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Precaution: Sodium azide is a poisonous and hazardous substance which should be handled by trained staff only.
• Applications: Incubating the peptide with equal volume of antibody for 30 min at 37°C usually completely blocks the activity of Anti-CCR5 in Western blot.
• Storage: When stored at -20°C, stable for one year from date of receipt.
• Concentration: 0.2 mg/ml

Gene Information

• Gene Name: CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) [ Homo sapiens(human) ]
• Official Symbol: CCR5
• Synonyms: CCR5; CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; chemokine (C-C motif) receptor 5 (gene/pseudogene); C-C chemokine receptor type 5; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A
• Gene ID: 1234
• mRNA Refseq: NM_000579
• Protein Refseq: NP_000570
• MIM: 601373
• UniProt ID: P51681
• Chromosome Location: 3p21.31
• Pathway: Binding and entry of HIV virion; Chemokine receptors bind chemokines; Chemokine signaling pathway
• Function: C-C chemokine binding; actin binding; chemokine (C-C motif) ligand 5 binding