Recombinant Mouse Chemokine (C-X-C motif) Ligand 3

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Recombinant Mouse Chemokine (C-X-C motif) Ligand 3

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Cat. No. : Cxcl3-373M
Product Overview : Recombinant humanCxcl3 is a single, non-glycosylated polypeptide chain containing 69 aminoacids.
Description : Cxcl3 is also known as MIP2β (macrophage inflammatoryprotein 2 beta), or DCIP1 (dendritic cell inflammatory protein1) in mouse,CINC2 (cytokineinduced neutrophil attractant 2) in rat, and GROγ (growthregulated oncogene gamma) in humans. It is an 8 kDa proinflammatory member ofthe CXC subfamily of heparinbinding chemokines, also called alpha chemokines.Mature mouse Cxcl3 shares 88% and 57% amino acid (aa)sequence identity with rat and human Cxcl3respectively.
Source : E. coli
Species : Mouse
Form : Lyophilized from a0.2µm filtered concentrated solution in 1×PBS, pH 7.4.
Molecular Weight : 7.7 kDa, a single,non-glycosylated polypeptide chain containing 69 amino acids.
Purity : >97% by SDS-PAGEand HPLC analyses.
Endotoxin Level : Less than 1EU/µg ofrMuDCIP-1/CXCL3 as determined by LAL method.
Biological Activity : Fully biologicallyactive when compared to standard. Determined by its ability to chemoattract293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml.
Sequence : SELRCQCLNTLPRVDFETIQ SLTVTPPGPH CTQTEVIATL KDGQEVCLNP QGPRLQIIIK KILKSGKSS
Reconstitution : We recommend thatthis vial be briefly centrifuged prior to opening to bring the contents tothe bottom. Reconstitute in sterile distilled water or aqueous buffercontaining 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutionsshould be apportioned into working aliquots and stored at ≤-20°C. Furtherdilutions should be made in appropriate buffered solutions.
Storage : This lyophilizedpreparation is stable for several weeks at 2-8°C, but should be kept at -20°Cfor long term storage, preferably desiccated. Upon reconstitution, thepreparation is stable for up to one week at 2-8°C. For maximal stability,apportion the reconstituted preparation into working aliquots and store at-20°C to -80°C. Avoid repeated freeze/thaw cycles.
OfficialSymbol : Cxcl3
Gene Name : Cxcl3 chemokine (C-X-C motif)ligand 3 [ Mus musculus ]
Synonyms : Cxcl3; chemokine(C-X-C motif) ligand 3; Dcip1; Gm1960; C-X-C motif chemokine 3; dendriticcell inflammatory protein 1
Gene ID : 330122
mRNA Refseq : NM_203320
Protein Refseq : NP_976065
UniProt ID : Q6W5C0
Chromosome Location : 5 E1; 5
Pathway : Chemokine receptorsbind chemokines; Class A/1 (Rhodopsin-like receptors); Cytokines andInflammatory Response (BioCarta); G alpha (i) signalling events; GPCRdownstream signaling; GPCR ligand binding; Peptide ligand-binding receptors;Senescence and Autophagy; Signal Transduction; Signaling by GPCR
Function : chemokine activity;cytokine activity; protein binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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