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Recombinant Human Fibroblast Growth Factor Receptor 1, His-tagged

Cat.No. : FGFR1-5417H
Product Overview : Recombinant humanFGFR1 catalytic domain (amino acids 308-731), His-tagged. No special measureswere taken to activate this kinase.
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  • Gene Information
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Cat. No. : FGFR1-5417H
Description : FGFs comprise a family of atleast eighteen structurally realted proteins that are involved in a multitudeof physiological and pathological cellular processes, including cell growth,differentation, angiogenesis, wound healing and tumorgenesis. The biologicalactivities of the FGFs are mediated by a family if type I transmembranetyrosine kinases which undergo dimerization and autophosphorylation afterligand binding.
Source : Insect cells
Species : Human
Form : Liquid in50 mM Tris, pH 7.5 + 100 mM NaCl + 0.2 mM EDTA + 0.05% Triton X-100 + 5mM DTT+ 50% glycerol.
Molecular Weight : 50.4 kDa
Purity : ≥ 90% as determinedby SDS-PAGE analysis
Specific Activity : 620 nmoleof phosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 2μg/ml.
Storage : Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : FGFR1
Gene Name : FGFR1 fibroblast growth factorreceptor 1 [ Homo sapiens ]
Synonyms : FGFR1; fibroblast growth factorreceptor 1; CEK; FLG; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; HBGFR; N-SAM;FLJ99988; fms-related tyrosine kinase 2; H2; H3; H4; H5; N-SAM; CD331;Pfeiffer syndrome; FGFR-1; bFGF-R; EC 2.7.10.1; Fms-like tyrosine kinase 2;c-fgr; CD_antigen; OTTHUMP00000190881; soluble FGFR1 variant 1; FMS-liketyrosine kinase 2; hydroxyaryl-protein kinase; heparin-binding growth factorreceptor; basic fibroblast growth factor receptor 1; OTTHUMP00000190874;OTTHUMP00000190878; OTTHUMP00000190879; c-fgr; soluble FGFR1 variant 2
Gene ID : 2260
mRNA Refseq : NM_015850
Protein Refseq : NP_056934
MIM : 136350
UniProt ID : P11362
Chromosome Location : 8p11.2-p11.1
Pathway : Adherens junction; Axonguidance; Developmental Biology; Downstream signaling of activated FGFR; EndochondralOssification; FGF signaling pathway; FGFR ligand binding and activation; FRS2-mediatedcascade; Glypican 1 network; IRS-mediated signalling; Insulin receptorsignalling cascade; L1CAM interactions; MAPK signaling pathway; Melanoma; N-cadherinsignaling events; Negative regulation of FGFR signaling
Function : ATP binding; fibroblast growthfactor receptor activity; fibroblast growth factor receptor activity; heparinbinding; nucleotide binding; protein binding; receptor activity; transferaseactivity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does DEFB103A interact with the human microbiome? 06/10/2022

DEFB103A plays a role in maintaining a balanced microbiome by exerting selective antimicrobial activity. Understanding this interaction is crucial for potential applications in microbiome-related disorders.

Can DEFB103A be used as a diagnostic marker for certain diseases? 05/01/2022

Research suggests that altered levels of DEFB103A expression may be associated with certain diseases. However, its specific use as a diagnostic marker requires further validation.

Are there any side effects or concerns associated with the therapeutic use of DEFB103A? 04/25/2022

While research is ongoing, potential side effects and concerns related to the therapeutic use of DEFB103A or its analogs need to be thoroughly investigated, including any possible immunogenicity.

How does DEFB103A contribute to the immune system? 02/08/2018

DEFB103A plays a crucial role in the innate immune system by acting as an antimicrobial peptide. It helps defend the body against a wide range of pathogens, including bacteria, viruses, and fungi.

What specific clinical conditions are associated with DEFB103A deficiency? 05/25/2017

DEFB103A deficiency has been linked to an increased susceptibility to various infections, particularly those affecting the skin and mucosal surfaces.

Customer Reviews (3)

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Reviews
05/01/2021

    FGFR1, a calcium-dependent phospholipid-binding protein, plays a crucial role in various cellular processes, making it a valuable tool for investigation.

    12/25/2018

      When combined with the support and quality assurance provided by the manufacturer, researchers can confidently utilize FGFR1 protein to unravel the intricate mechanisms underlying cellular processes, ultimately advancing scientific knowledge.

      07/24/2017

        The manufacturer can contribute to the research process by providing top-quality FGFR1 protein that meets rigorous standards of purity, stability, and reliability.

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