"FLT1" Related Products


Recombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Cat. No. : FLT1-1221H
Product Overview : Recombinant humansoluble FLT1 is the naturally occurring form and was cloned from total RNA ofhuman umbilical vein endothelial cells.
Description : The recombinant mature soluble FLT1 is aglycosylated monomeric protein consisting of the first 6 extracellulardomains (Met1-His688) containing the unique 31 amino acid residues at theC-terminus.
Source : Insect cells
Species : Human
Form : Lyophilizedwithout additives.
Molecular Weight : 96 kDa
Purity : > 90% asdetermined by SDS-PAGE and visualized by silver stain
Endotoxin Level : < 0.1 ng/µg of FLT1
Biological Activity : Determined by itsability to abolish the binding of iodinated FLT1 to solid surfaces or cellsurface receptors. The ED50 for this effect is typically 10 ng/ml. The usablerange is 5-50 ng/ml.
Reconstitution : Centrifugevial prior to opening. Soluble in water and most aqueous buffers. Add PBS tothe vial to fully solubilize the protein to a concentration not lower than100 ng/ml.
Storage : Lyophilized proteinis stable for 6 months at -20°C to -80°C. Store reconstituted protein inworking aliquots at -20°C. Avoid repeated freeze-thaw cycles.
PDBrendering based on 1flt. :

Gene Name : FLT1 fms-related tyrosine kinase 1(vascular endothelial growth factor/vascular permeability factor receptor) [ Homosapiens ]
Official Symbol : FLT1
Synonyms : FLT1; fms-related tyrosinekinase 1 (vascular endothelial growth factor/vascular permeability factorreceptor); FLT; VEGFR1; FRT; vascular endothelial growth factor receptor 1;EC; VEGFR-1; Vascular permeability factor receptor; Flt-1;Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; Fms-liketyrosine kinase 1
Gene ID : 2321
mRNA Refseq : NM_001159920
Protein Refseq : NP_001153392
MIM : 165070
UniProt ID : P17948
Chromosome Location : 13q12
Pathway : Cytokine-cytokinereceptor interaction; Endocytosis; Focal Adhesion; Glypican 1 network;HIF-2-alpha transcription factor network; Id Signaling Pathway; Neurophilininteractions with VEGF and VEGFR; Rheumatoid arthritis; S1P3 pathway; SignalTransduction; Signaling by VEGF; Signaling events mediated by VEGFR1 andVEGFR2; VEGF binds to VEGFR leading to receptor dimerization; VEGFligand-receptor interactions; VEGFR1 specific signals
Function : ATP binding; growth factorbinding; identical protein binding; nucleotide binding; receptor activity;transferase activity; vascular endothelial growth factor receptor activity

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