"FLT1" Related Products


Recombinant Human Fms-Related Tyrosine Kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), His-tagged

Cat. No. : FLT1-1222H
Product Overview : Recombinant humanFLT1 containing amino acids 783-end and an N-terminal His tag.
Description : FLT1is a protein that in humans is encoded by the FLT1 gene. FLT1 belongs to thesrc gene family and is related to oncogene ROS. Like other members of thisfamily, it shows tyrosine protein kinase activity that is important for thecontrol of cell proliferation and differentiation.
Source : Baculovirus infectedSf9 cells
Species : Human
Form : Liquid in25 mM Tris-HCl, pH 8.0 + 100 mM NaCl + 0.05% Tween-20 + 50% glycerol + 3 mMDTT.
Molecular Weight : 67.5 kDa
Specific Activity : 170 U/mg. One unitis defined as the amount of enzyme that will transfer 1 nmol phosphate to thetyrosine substrate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES,pH 7.4 + 3 mM MgCl2 + 3 mM MnCl2 + 1 mM DTT + 3 µM Na-orthovanadate + 0.1 mMATP + 30 µg/ml Poly (Glu:Tyr)4:1 substrate + 2 µg /ml recombinant FLT1.
Storage : Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
PDBrendering based on 1flt. :

Gene Name : FLT1 fms-related tyrosine kinase 1(vascular endothelial growth factor/vascular permeability factor receptor) [ Homosapiens ]
Official Symbol : FLT1
Synonyms : FLT1; fms-related tyrosinekinase 1 (vascular endothelial growth factor/vascular permeability factorreceptor); FLT; VEGFR1; FRT; vascular endothelial growth factor receptor 1;EC; VEGFR-1; Vascular permeability factor receptor; Flt-1;Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; Fms-liketyrosine kinase 1
Gene ID : 2321
mRNA Refseq : NM_001159920
Protein Refseq : NP_001153392
MIM : 165070
UniProt ID : P17948
Chromosome Location : 13q12
Pathway : Cytokine-cytokinereceptor interaction; Endocytosis; Focal Adhesion; Glypican 1 network;HIF-2-alpha transcription factor network; Id Signaling Pathway; Neurophilininteractions with VEGF and VEGFR; Rheumatoid arthritis; S1P3 pathway; SignalTransduction; Signaling by VEGF; Signaling events mediated by VEGFR1 andVEGFR2; VEGF binds to VEGFR leading to receptor dimerization; VEGFligand-receptor interactions; VEGFR1 specific signals
Function : ATP binding; growth factorbinding; identical protein binding; nucleotide binding; receptor activity;transferase activity; vascular endothelial growth factor receptor activity

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