Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog (avian), His-tagged

• Cat.No.: ERBB2-1215H
• Product Overview: Recombinant humanERBB2 cytoplasmic domain (aa 676-1255) with His tag. No special measures weretaken to activate this kinase.

Specification

• Cat. No.: ERBB2-1215H
• Description: ERBB2 stands for"Human Epidermal growth factor Receptor 2" and is a protein givinghigher aggressiveness in breast cancers.It is a member of the ErbB protein family, more commonly knownas the epidermal growth factor receptor family. HER2/neu has also beendesignated as CD340 (cluster ofdifferentiation 340) and p185. It is encoded by the ERBB2 gene.
• Source: Insect cells
• Species: Human
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.01% CHAPS + 2 Mm DTT + 50%glycerol.
• Molecular Weight: 68.6 kDa
• Storage: Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: ERBB2

Gene Information

• Gene Name: ERBB2 v-erb-b2 erythroblasticleukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogenehomolog (avian) [ Homo sapiens ]
• Synonyms: ERBB2; v-erb-b2erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derivedoncogene homolog (avian); NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19;HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogeneNeu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph nodegene 19 protein; tyrosine kinase-type cell surface receptor HER2; neuroblastoma/glioblastomaderived oncogene homolog; v-erb-b2 avian erythroblastic leukemia viraloncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
• Gene ID: 2064
• mRNA Refseq: NM_004448
• Protein Refseq: NP_004439
• MIM: 164870
• UniProt ID: P04626
• Chromosome Location: 17q11.2-q12
• Pathway: Adherens junction;Alpha6-Beta4 Integrin Signaling Pathway; Axon guidance; Bladder cancer; Calciumsignaling pathway; Developmental Biology; Endometrial cancer; ErbB receptorsignaling network; ErbB signaling pathway; ErbB2/ErbB3 signaling events;Focal Adhesion; Focal adhesion; Non-small cell lung cancer; Pancreaticcancer; Sema4D in semaphorin signaling
• Function: ATP binding; ErbB-3class receptor binding; Hsp90 protein binding; RNA polymerase I core binding;epidermal growth factor-activated receptor activity; glycoprotein binding;contributes_to growth factor binding; identical protein binding; nucleotidebinding; protein C-terminus binding; protein binding; protein dimerizationactivity; protein heterodimerization activity; protein phosphatase binding;receptor activity