Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), His-tagged
Cat.No. : | ERBB3-1216H |
Product Overview : | Recombinant HumanTyrosine Kinase ERBB3 (extracellular domain) is a single, nonglycosylated, fusionpolypeptide chain containing Thyrodoxin Tag and His tag. The protein consistsof 190 amino acids (Met1- Cys190). |
- Specification
- Gene Information
- Related Products
Cat. No. : | ERBB3-1216H |
Description : | ERBB3 is an enzyme that in humans is encoded by theERBB3 gene. This gene encodes a member of theepidermal growth factor receptor (EGFR) family of receptor tyrosine kinases.This membrane-bound protein has a neuregulin binding domain but not an activekinase domain. It therefore can bind this ligand but not convey the signalinto the cell through protein phosphorylation. |
Source : | E. coli |
Species : | Human |
Form : | Liquid. Each mg ofprotein contains 1 mg aluminum hydroxide + 10 mM arginine + 10 mM sodiumchloride + 20 mM sodium phosphate buffer + 5 mM potassium phosphate. |
Molecular Weight : | 34 kDa |
Concentration : | 1 mg/ml |
Purity : | > 95.0% asdetermined by RP-HPLC and SDS-PAGE analyses. |
Endotoxin Level : | < 0.1 ng/ug ofERBB3. |
Biological Activity : | Determined by itsability to postpone tumor emerge time of spontaneous breast cancer in FVB/Ntransgenic mice and inhibit the development of tumor and growth of in situ transplantedbreast cancer in FVB/N transgenic mice. |
Amino Acid Sequence : | MRANDALQVLGLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM GNLEIVLTGH NADLSFLQWIREVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDTIDWRDIVRDR DAEIVVKDNG RSCPPCHEVC |
Storage : | Storeat -20°C to -80°C with a carrier protein (0.1% HSA orBSA) as a stabilizer for long term storage. Please note that the addition ofany carrier protein into this product may produce unwanted endotoxin. Thisdepends upon the particular application employed. Avoid repeated freeze-thawcycles. |
OfficialSymbol : | ERBB3 |
Gene Name : | ERBB3 v-erb-b2 erythroblasticleukemia viral oncogene homolog 3 (avian) [ Homo sapiens ] |
Synonyms : | ERBB3; v-erb-b2erythroblastic leukemia viral oncogene homolog 3 (avian); HER3; LCCS2;ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; MGC88033; c-erbB-3; p180-ErbB3;p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3;OTTHUMP00000243039; OTTHUMP00000243040; OTTHUMP00000243072;OTTHUMP00000243359; OTTHUMP00000243360; proto-oncogene-like protein c-ErbB-3;tyrosine kinase-type cell surface receptor HER3 |
Gene ID : | 2065 |
mRNA Refseq : | NM_001982 |
Protein Refseq : | NP_001973 |
MIM : | 190151 |
UniProt ID : | P21860 |
Chromosome Location : | 12q13 |
Pathway : | Calcium signalingpathway; Endocytosis; ErbB receptor signaling network; ErbB signalingpathway; ErbB2/ErbB3 signaling events; Heart Development; IL-6 SignalingPathway; a6b1 and a6b4 Integrin signaling |
Function : | ATP binding; growthfactor binding; nucleotide binding; protein binding; proteinheterodimerization activity; protein tyrosine kinase activator activity; NOTprotein tyrosine kinase activity; receptor activity; receptor signalingprotein tyrosine kinase activity; transmembrane receptor protein tyrosinekinase activity; transmembrane signaling receptor activity |
Products Types
◆ Recombinant Protein | ||
ERBB3-383H | Recombinant Human ERBB3 Protein, His-tagged | +Inquiry |
ERBB3-207H | Recombinant Human ERBB3 Protein(Ser20-Thr643), His-Avi-tagged, FITC-Labeled | +Inquiry |
ERBB3-236H | Recombinant Human ERBB3 Protein, His-tagged | +Inquiry |
ERBB3-7276H | Active Recombinant Human ERBB3 protein(Pro 730-Ser 1065), His&GST-tagged | +Inquiry |
ERBB3-197H | Recombinant Human ERBB3 Protein | +Inquiry |
◆ Lysates | ||
ERBB3-1721RCL | Recombinant Rhesus ERBB3 cell lysate | +Inquiry |
ERBB3-939HCL | Recombinant Human ERBB3 cell lysate | +Inquiry |
ERBB3-1415RCL | Recombinant Rat ERBB3 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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