Cat. No.:	HCK-1235H
Product Overview:	Recombinant humanfull length HCK with C-terminal His tag. No special measures were taken toactivate this kinase.
Description:	Theprotein encoded by this gene is a HCK that ispredominantly expressed in hemopoietic cell types, and belongs to the Srcfamily of tyrosine kinases. The encoded protein may help couple the Fcreceptor to the activation of the respiratory burst. In addition, it may playa role in neutrophil migration and in the degranulation of neutrophils.Alternate translation initiation site usage, including a non-AUG (CUG) codon,results in the production of two different isoforms, that have differentsubcellular localization.
Source:	Insect cells
Species:	Human
Form:	Liquid in 50 mMTris, pH 7.5 + 0.05 mM EDTA + 1 mM DTT + 100 mM NaCl + 0.05% NP-40 + 50%glycerol.
Molecular Weight:	58.7 kDa
Specific Activity:	1450 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg oftotal protein at 30°C. Activity determined at a final protein concentrationof 2 µg/ml.
Storage:	Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol:	HCK

Gene Name:	HCK hemopoietic cell kinase [ Homosapiens ]
Synonyms:	HCK; hemopoietic cell kinase;JTK9; Tyrosine-protein kinase HCK; EC2.7.10.2; Hemopoietic cell kinase; p59-HCK/p60-HCK
Gene ID:	3055
mRNA Refseq:	NM_002110
Protein Refseq:	NP_002101
MIM:	142370
UniProt ID:	P08631
Chromosome Location:	20q11-q12
Pathway:	Alpha-synuclein signaling; B Cell ReceptorSignaling Pathway; CXCR4-mediated signaling events; Chemokine signalingpathway; Class I PI3K signaling events; Cytokine Signaling in Immune system; EPHAforward signaling; Ephrin B reverse signaling; Fc gamma R-mediatedphagocytosis; Focal Adhesion; Glypican 1 network; HIV Infection; IL-3Signaling Pathway; IL-5 Signaling Pathway; Immune System
Function:	ATP binding; non-membranespanning protein tyrosine kinase activity; nucleotide binding; proteinbinding; transferase activity

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