Expand| Cat. No. : | HCK-1235H |
| Product Overview : | Recombinant humanfull length HCK with C-terminal His tag. No special measures were taken toactivate this kinase. |
| Description : | Theprotein encoded by this gene is a HCK that ispredominantly expressed in hemopoietic cell types, and belongs to the Srcfamily of tyrosine kinases. The encoded protein may help couple the Fcreceptor to the activation of the respiratory burst. In addition, it may playa role in neutrophil migration and in the degranulation of neutrophils.Alternate translation initiation site usage, including a non-AUG (CUG) codon,results in the production of two different isoforms, that have differentsubcellular localization. |
| Source : | Insect cells |
| Species : | Human |
| Form : | Liquid in 50 mMTris, pH 7.5 + 0.05 mM EDTA + 1 mM DTT + 100 mM NaCl + 0.05% NP-40 + 50%glycerol. |
| Molecular Weight : | 58.7 kDa |
| Specific Activity : | 1450 nmole ofphosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute per mg oftotal protein at 30°C. Activity determined at a final protein concentrationof 2 µg/ml. |
| Storage : | Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles. |
| OfficialSymbol : | HCK |
| PDBrendering based on 1ad5. : |
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| Gene Name : | HCK hemopoietic cell kinase [ Homosapiens ] |
| Synonyms : | HCK; hemopoietic cell kinase;JTK9; Tyrosine-protein kinase HCK; EC2.7.10.2; Hemopoietic cell kinase; p59-HCK/p60-HCK |
| Gene ID : | 3055 |
| mRNA Refseq : | NM_002110 |
| Protein Refseq : | NP_002101 |
| MIM : | 142370 |
| UniProt ID : | P08631 |
| Chromosome Location : | 20q11-q12 |
| Pathway : | Alpha-synuclein signaling; B Cell ReceptorSignaling Pathway; CXCR4-mediated signaling events; Chemokine signalingpathway; Class I PI3K signaling events; Cytokine Signaling in Immune system; EPHAforward signaling; Ephrin B reverse signaling; Fc gamma R-mediatedphagocytosis; Focal Adhesion; Glypican 1 network; HIV Infection; IL-3Signaling Pathway; IL-5 Signaling Pathway; Immune System |
| Function : | ATP binding; non-membranespanning protein tyrosine kinase activity; nucleotide binding; proteinbinding; transferase activity |
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