Recombinant Human Tryptophan 2,3-Dioxygenase, T7-tagged
Cat.No. : | TDO2-823H |
Product Overview : | Recombinant TDO2 protein was expressed in E.coli with T7-tag at the N-terminus. The molecular weight is 47872 Da. |
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Species : | Human |
Source : | E.coli |
Tag : | T7 |
Description : | In Anopheles gambiae tryptophan 2,3-dioxygenase (TDO) is the only enzyme able to catalyze the first and ratelimiting step in L-Trp catabolism through the kynurenine pathway. On the contrary, in mammals, L-Trp can enter the kynurenine pathway through the alternative action of two enzymes, TDO and Indoleamine 2,3-dioxygenase (IDO). TDO converts L-tryptophan to N- formyl kynurenine by catalyzing the heme-dependent oxidative opening of the substrate indole ring. The metabolism of L-tryptophan (L-Trp) exceeding the protein synthesis requirements proceeds through several routes, generating a number of compounds that play multiple roles in controlling basic aspects of the biology of most living organisms. |
Sequences of amino acids : | 1-406 aa |
Formulation : | 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT. |
Purity : | 95% |
Gene Name | TDO2 tryptophan 2,3-dioxygenase [ Homo sapiens ] |
Synonyms | TDO; TPH2; TRPO; TDO2; tryptophan 2,3-dioxygenase; TO; tryptophanase; tryptophan oxygenase; tryptophan pyrrolase; tryptamin 2,3-dioxygenase;EC 1.13.11.11 |
Gene ID | 6999 |
mRNA Refseq | NM_005651 |
Protein Refseq | NP_005642 |
MIM | 191070 |
UniProt ID | P48775 |
Chromosome Location | 4q31-q32 |
Pathway | Metabolic pathways; Tryptophan metabolism; Metabolism of amino acids and derivatives |
Function | amino acid binding; heme binding; metal ion binding; oxidoreductase activity; oxygen binding; oxygen binding; tryptophan 2,3-dioxygenase activity |
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TDO2-3558H | Recombinant Human TDO2 protein, His-SUMO-tagged | +Inquiry |
TDO2-2503H | Recombinant Human Tryptophan 2,3-Dioxygenase, His-tagged | +Inquiry |
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◆ Cell & Tissue Lysates | ||
TDO2-1156HCL | Recombinant Human TDO2 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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