Cat. No.:	TDO2-823H
Product Overview:	Recombinant TDO2 protein was expressed in E.coli with T7-tag at the N-terminus. The molecular weight is 47872 Da.
Description:	In Anopheles gambiae tryptophan 2,3-dioxygenase (TDO) is the only enzyme able to catalyze the first and ratelimiting step in L-Trp catabolism through the kynurenine pathway. On the contrary, in mammals, L-Trp can enter the kynurenine pathway through the alternative action of two enzymes, TDO and Indoleamine 2,3-dioxygenase (IDO). TDO converts L-tryptophan to N- formyl kynurenine by catalyzing the heme-dependent oxidative opening of the substrate indole ring. The metabolism of L-tryptophan (L-Trp) exceeding the protein synthesis requirements proceeds through several routes, generating a number of compounds that play multiple roles in controlling basic aspects of the biology of most living organisms.
Sequences of amino acids:	1-406 aa
Formulation:	10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.
Purity:	95%

Gene Name:	TDO2 tryptophan 2,3-dioxygenase [ Homo sapiens ]
Synonyms:	TDO; TPH2; TRPO; TDO2; tryptophan 2,3-dioxygenase; TO; tryptophanase; tryptophan oxygenase; tryptophan pyrrolase; tryptamin 2,3-dioxygenase;EC 1.13.11.11
Gene ID:	6999
mRNA Refseq:	NM_005651
Protein Refseq:	NP_005642
MIM:	191070
UniProt ID:	P48775
Chromosome Location:	4q31-q32
Pathway:	Metabolic pathways; Tryptophan metabolism; Metabolism of amino acids and derivatives
Function:	amino acid binding; heme binding; metal ion binding; oxidoreductase activity; oxygen binding; oxygen binding; tryptophan 2,3-dioxygenase activity

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