Recombinant Human Tryptophan 2,3-Dioxygenase, T7-tagged

Cat.No. : TDO2-823H
Product Overview : Recombinant TDO2 protein was expressed in E.coli with T7-tag at the N-terminus. The molecular weight is 47872 Da.
  • Specification
  • Gene Information
  • Related Products
  • Download
Species : Human
Source : E.coli
Tag : T7
Description : In Anopheles gambiae tryptophan 2,3-dioxygenase (TDO) is the only enzyme able to catalyze the first and ratelimiting step in L-Trp catabolism through the kynurenine pathway. On the contrary, in mammals, L-Trp can enter the kynurenine pathway through the alternative action of two enzymes, TDO and Indoleamine 2,3-dioxygenase (IDO). TDO converts L-tryptophan to N- formyl kynurenine by catalyzing the heme-dependent oxidative opening of the substrate indole ring. The metabolism of L-tryptophan (L-Trp) exceeding the protein synthesis requirements proceeds through several routes, generating a number of compounds that play multiple roles in controlling basic aspects of the biology of most living organisms.
Sequences of amino acids : 1-406 aa
Formulation : 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3. 10mM DTT.
Purity : 95%
Gene Name TDO2 tryptophan 2,3-dioxygenase [ Homo sapiens ]
Synonyms TDO; TPH2; TRPO; TDO2; tryptophan 2,3-dioxygenase; TO; tryptophanase; tryptophan oxygenase; tryptophan pyrrolase; tryptamin 2,3-dioxygenase;EC 1.13.11.11
Gene ID 6999
mRNA Refseq NM_005651
Protein Refseq NP_005642
MIM 191070
UniProt ID P48775
Chromosome Location 4q31-q32
Pathway Metabolic pathways; Tryptophan metabolism; Metabolism of amino acids and derivatives
Function amino acid binding; heme binding; metal ion binding; oxidoreductase activity; oxygen binding; oxygen binding; tryptophan 2,3-dioxygenase activity

Not For Human Consumption!

Inquiry

  • Reviews (0)
  • Q&As (0)

Customer Reviews

Write a review

Ask a Question for All TDO2 Products

Required fields are marked with *

My Review for All TDO2 Products

Required fields are marked with *

0
cart-icon