"MAP3K5" Related Products

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Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 5, GST-tagged

Cat. No. : MAP3K5-1260H
Product Overview : RecombinantHuman MAP3K5 with N-terminal GST tag. MAP3K5 is a serine/threonine kinasethat is abundantly expressed in human heart and pancreas.
Description : The MAP3K5protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro,and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase(SAPK) during transient expression in COS and 293 cells; MAP3K5 does notactivate MAPK/ERK.
Source : Insect cells
Species : Human
Form : Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol.
Molecular Weight : 182 kDa
Specific Activity : 64 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 8.33μg/ml.
Concentration : 0.25mg/ml
Storage : Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : MAP3K5
nullValue_other :
FunctionMAP kinase kinasekinase activity; metal ion binding; protein kinase activity; nucleotidebinding; protein serine/tyreonine kinase activity; protein phosphatase binding;protein homodimerization activity; protein binding; magnesium ion binding; cysteine-typeendopeptidase activator activity involved in apoptotic process
PDB rendering basedon 2clq. :

Gene Name : MAP3K5 mitogen-activated proteinkinase kinase kinase 5 [ Homo sapiens ]
Synonyms : MAP3K5; mitogen-activatedprotein kinase kinase kinase 5; MEKK5; MAPKKK5; ASK1; apoptosissignal regulating kinase 1; OTTHUMP00000017275; EC 2.7.11.25; ASK-1; MEKkinase 5; MAPK/ERK kinase kinase 5; MAP/ERK kinase kinase 5; apoptosis signal-regulatingkinase 1
Gene ID : 4217
mRNA Refseq : NM_005923
Protein Refseq : NP_005914
MIM : 602448
UniProt ID : Q99683
Chromosome Location : 6q22.33
Pathway : p38 MAPK signalingpathway; Protein processing in endoplasmic reticulum; Class I PI3K signalingevents mediated by Akt; Amyotrophic lateral sclerosis (ALS); HTLV-Iinfection;IL1-mediatedsignaling events; Neurotrophin signaling pathway; InsulinSignaling; TNFreceptor signaling pathway; MAPK Cascade; MAPK signaling pathway; TNF-alpha/NF-kBSignaling Pathway; Trk receptor signaling mediated by the MAPK pathway

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