"IGF2" Related Products

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Recombinant Human Insulin-Like Growth Factor 2 (somatomedin A)

Cat. No. : IGF2-5430H
Product Overview : Recombinant humanIGF2 was expressed in E. coli.
Description : Human Insulin-likeGrowth Factor-II (IGF-II) is a single chain 67 amino acid polypeptide thatshares structural homology with insulin and human IGF-I. Human IGF-II iswidely distributed in many tissues throughout the body and acts on numerouscell types through the Type 1 IGF-I receptor. IGF-II also binds specificallyto the IGF-II / cation-independent mannose-6-phosphate receptor as well asthe family of six IGF binding proteins, but the physiological function ofIGF-II as a result of all these interactions has not been clearlyestablished.
Source : E. coli
Species : Human
Purity : Greater than 95% (byHPLC and N-terminal sequence analysis).
Molecular Weight : 7.649kDa-homogeneity confirmed by Mass Spectometry.
Endotoxin Level : Less than 0.1 EU/ug
Biological Activity : Type 1 IGF receptorbinding assay: ED50>20 ng/ml. Type 2 IGF receptor binding assay: ED50<70ng/ml. IGF binding protein assay: ED50<10 ng/ml. Stimulation of proteinsynthesis in rat L6 myoblasts: ED50 Less than 150 ng/ml.
State and appearance : Lyophilized whitepowder.
N-terminal sequenceanalysis : 7 residues Greaterthan 95% single sequence.
Reconstitution : Refer to Protocol1000: Handling of GroPep IGF-I, IGF-II and IGF Analogs.
Storage : At least 2 years at2-4°C (lyophilized).
OfficialSymbol : IGF2
PDBrendering based on 1igl. :

Gene Name : IGF2 insulin-like growth factor2 (somatomedin A) [ Homo sapiens ]
Synonyms : IGF2; insulin-likegrowth factor 2 (somatomedin A); IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734;insulin-like growth factor II;somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013; OTTHUMP00000011015;OTTHUMP00000011018; OTTHUMP00000011157; OTTHUMP00000011158;OTTHUMP00000220677; insulin-like growth factor type 2
Gene ID : 3481
mRNA Refseq : NM_000612
Protein Refseq : NP_000603
MIM : 147470
UniProt ID : P01344
Chromosome Location : 11p15
Pathway : Apoptosis;Diabetes pathways; Endochondral Ossification; Hedgehog Signaling Pathway;Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-likeGrowth Factor Binding Proteins (IGFBPs)
Function : growthfactor activity; hormone activity; insulin receptor binding; insulin-likegrowth factor receptor binding; protein binding; protein serine/threoninekinase activator activity; receptor activator activity

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