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Recombinant Human Insulin-Like Growth Factor 2 (somatomedin A)

Cat.No. : IGF2-5430H
Product Overview : Recombinant humanIGF2 was expressed in E. coli.
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Cat. No. : IGF2-5430H
Description : Human Insulin-likeGrowth Factor-II (IGF-II) is a single chain 67 amino acid polypeptide thatshares structural homology with insulin and human IGF-I. Human IGF-II iswidely distributed in many tissues throughout the body and acts on numerouscell types through the Type 1 IGF-I receptor. IGF-II also binds specificallyto the IGF-II / cation-independent mannose-6-phosphate receptor as well asthe family of six IGF binding proteins, but the physiological function ofIGF-II as a result of all these interactions has not been clearlyestablished.
Source : E. coli
Species : Human
Purity : Greater than 95% (byHPLC and N-terminal sequence analysis).
Molecular Weight : 7.649kDa-homogeneity confirmed by Mass Spectometry.
Endotoxin Level : Less than 0.1 EU/ug
Biological Activity : Type 1 IGF receptorbinding assay: ED50>20 ng/ml. Type 2 IGF receptor binding assay: ED50<70ng/ml. IGF binding protein assay: ED50<10 ng/ml. Stimulation of proteinsynthesis in rat L6 myoblasts: ED50 Less than 150 ng/ml.
State and appearance : Lyophilized whitepowder.
N-terminal sequenceanalysis : 7 residues Greaterthan 95% single sequence.
Reconstitution : Refer to Protocol1000: Handling of GroPep IGF-I, IGF-II and IGF Analogs.
Storage : At least 2 years at2-4°C (lyophilized).
OfficialSymbol : IGF2
Gene Name : IGF2 insulin-like growth factor2 (somatomedin A) [ Homo sapiens ]
Synonyms : IGF2; insulin-likegrowth factor 2 (somatomedin A); IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734;insulin-like growth factor II;somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013; OTTHUMP00000011015;OTTHUMP00000011018; OTTHUMP00000011157; OTTHUMP00000011158;OTTHUMP00000220677; insulin-like growth factor type 2
Gene ID : 3481
mRNA Refseq : NM_000612
Protein Refseq : NP_000603
MIM : 147470
UniProt ID : P01344
Chromosome Location : 11p15
Pathway : Apoptosis;Diabetes pathways; Endochondral Ossification; Hedgehog Signaling Pathway;Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-likeGrowth Factor Binding Proteins (IGFBPs)
Function : growthfactor activity; hormone activity; insulin receptor binding; insulin-likegrowth factor receptor binding; protein binding; protein serine/threoninekinase activator activity; receptor activator activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can IGF2 be used as a predictive marker for certain diseases? 11/12/2021

Yes, IGF2 levels may serve as predictive markers for certain diseases. Monitoring its expression could help identify individuals at risk or track disease progression.

How can IGF2 be targeted for therapeutic interventions? 04/20/2021

Researchers are exploring various approaches, including drug development, to modulate IGF2 levels for therapeutic purposes. This may involve targeting its receptors or modifying its expression.

How does IGF2 relate to aging and age-related diseases? 12/28/2020

IGF2 has been linked to the aging process and age-related diseases. Exploring its role may provide insights into slowing down aging or managing age-related conditions.

Are there therapeutic applications of IGF2 in regenerative medicine? 12/08/2020

Research is exploring the potential use of IGF2 in regenerative medicine due to its role in cell growth and tissue repair. It may offer new avenues for tissue regeneration.

Are there clinical trials exploring IGF2 as a therapeutic target? 05/21/2019

Yes, there are ongoing clinical trials investigating the use of IGF2 in various conditions. These trials aim to assess its safety and efficacy in a clinical setting.

Customer Reviews (3)

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Reviews
01/24/2023

    The IGF2 protein is an exceptional choice that meets the highest standards of quality, making it perfectly suited for your experimental needs.

    01/26/2019

      The IGF2 protein is of the highest quality and perfectly suited for your experimental requirements.

      01/20/2019

        In addition to its exceptional quality, the IGF2 protein is backed by excellent technical support offered by the manufacturer.

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