Recombinant Human Insulin-Like Growth Factor 2 (somatomedin A)

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Recombinant Human Insulin-Like Growth Factor 2 (somatomedin A)

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Cat. No. : IGF2-5431H
Product Overview : Recombinant humanIGF2 was expressed in E. coli.
Description : The IGF-II geneencodes a single transcript which results in an 156 amino acid protein,including an 89 amino acid E-domain. ProIGF-II contains sites of O-linkedglycosylation. ProIGF-II is converted to mature IGF-II by sequential cleavageafter amino acids 104, 87 and 67. Differential glycosylation and cleavagewithin the E-domain can therefore result in multiple proIGF-II isoforms.
Source : E. coli
Species : Human
Purity : Greater than 95% (byHPLC and N-terminal sequence analysis).
Molecular Weight : 11.949 kDa-confirmedby Mass Spectometry.
Endotoxin Level : Less than 0.1 EU/ug
Biological Activity : Stimulation ofprotein synthesis in rat L6 myoblasts.
State and appearance : Lyophilized whitepowder.
N-terminal sequenceanalysis : 5 residues Greaterthan 95% single sequence.
Reconstitution : Refer to Protocol1000: Handling of GroPep IGF-I, IGF-II and IGF Analogs.
Storage : At least 2 years at2-4°C (lyophilized).
OfficialSymbol : IGF2
Gene Name : IGF2 insulin-like growth factor2 (somatomedin A) [ Homo sapiens ]
Synonyms : IGF2; insulin-likegrowth factor 2 (somatomedin A); IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734;insulin-like growth factor II;somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013; OTTHUMP00000011015;OTTHUMP00000011018; OTTHUMP00000011157; OTTHUMP00000011158;OTTHUMP00000220677; insulin-like growth factor type 2
Gene ID : 3481
mRNA Refseq : NM_000612
Protein Refseq : NP_000603
MIM : 147470
UniProt ID : P01344
Chromosome Location : 11p15
Pathway : Apoptosis;Diabetes pathways; Endochondral Ossification; Hedgehog Signaling Pathway;Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-likeGrowth Factor Binding Proteins (IGFBPs)
Function : growthfactor activity; hormone activity; insulin receptor binding; insulin-likegrowth factor receptor binding; protein binding; protein serine/threoninekinase activator activity; receptor activator activity

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