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Recombinant Human KIT Ligand

Cat.No. : KITLG-1245H
Product Overview : Recombinant Human KITLGis expressed in human 293 cells as a monomeric glycoprotein with an apparent molecularmass of 35 to 45 kDa.
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Cat. No. : KITLG-1245H
Description : KITLG (also knownas SCF, kit-ligand, KL, or steel factor) is a cytokine that binds to thec-Kit receptor (CD117). KITLG can exist both as a transmembrane protein and asoluble protein. This cytokine plays an important role in hematopoiesis(formation of blood cells), spermatogenesis, and melanogenesis.
Source : HEK 293 cells
Species : Human
MolecularWeight : 35 to 45 kDa,monomer, glycosylated
Purity : >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel wasstained with Coomassie blue.
Endotoxin Level : Endotoxin Free<1 EU/µg
Biological Activity : 5 to 25 ng/mL ED50
Specific Activity : The specificactivity was determined by the dose-dependent stimulation of the proliferationof human TF-1 cells (human erythroleukemic indicator cell line).
OfficialSymbol : KITLG
Gene Name : KITLG KIT ligand [ Homosapiens ]
Synonyms : KITLG; KIT ligand;SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; kit-ligand; DKFZp686F2250; kit ligand;c-Kit ligand; steel factor; stem cell factor; OTTHUMP00000242388;OTTHUMP00000242389; OTTHUMP00000242390; mast cell growth factor; familialprogressive hyperpigmentation 2
Gene ID : 4254
mRNA Refseq : NM_000899
Protein Refseq : NP_000890
MIM : 184745
UniProt ID : P21583
Chromosome Location : 12q22
Pathway : C-MYB transcriptionfactor network; Cytokine-cytokine receptor interaction; Hematopoietic celllineage; Kit Receptor Signaling Pathway; Melanogenesis; Pathways in cancer;Regulation of KIT signaling; Signal Transduction; Signaling by SCF-KIT;Signaling events mediated by Stem cell factor receptor (c-Kit)
Function : cytokine activity;growth factor activity; protein binding; stem cell factor receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does KITLG influence stem cell factor (SCF) signaling pathways? 11/10/2022

Overexpression or mutations in KITLG and its receptor have been implicated in various cancers, including gastrointestinal stromal tumors (GISTs), mastocytosis, and certain leukemias.

What are the implications of KITLG in oncogenesis and tumor progression? 07/20/2022

Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.

What role does KITLG play in melanogenesis and pigmentation? 01/17/2022

Dysregulation or mutations in KITLG have been associated with certain disorders like piebaldism, a genetic condition characterized by unpigmented patches of skin and hair.

Are there any known disorders associated with mutations or dysregulation of KITLG? 06/22/2020

Upon binding to c-KIT, KITLG activates the SCF signaling pathways, which include the MAPK, PI3K, and JAK/STAT pathways, influencing cell survival, proliferation, and differentiation.

What is the primary biological function of KITLG in the hematopoietic system? 04/12/2020

KITLG binds to the c-KIT receptor, a tyrosine kinase receptor, leading to its dimerization and autophosphorylation, which activates downstream signaling pathways.

How has KITLG been explored as a therapeutic target or agent in clinical settings? 02/10/2020

Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.

How does KITLG interact with its receptor, c-KIT? 12/21/2019

KITLG and its receptor c-KIT are involved in melanogenesis. Their interaction regulates the proliferation and migration of melanocytes, influencing skin, hair, and eye pigmentation.

Customer Reviews (3)

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Reviews
01/23/2022

    Reliable for immunoprecipitation assay.

    03/01/2021

      No contamination, very clean.

      02/09/2020

        Worked perfectly in Western.

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