Recombinant Human KIT Ligand
Cat.No. : | KITLG-1245H |
Product Overview : | Recombinant Human KITLGis expressed in human 293 cells as a monomeric glycoprotein with an apparent molecularmass of 35 to 45 kDa. |
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- Gene Information
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Cat. No. : | KITLG-1245H |
Description : | KITLG (also knownas SCF, kit-ligand, KL, or steel factor) is a cytokine that binds to thec-Kit receptor (CD117). KITLG can exist both as a transmembrane protein and asoluble protein. This cytokine plays an important role in hematopoiesis(formation of blood cells), spermatogenesis, and melanogenesis. |
Source : | HEK 293 cells |
Species : | Human |
MolecularWeight : | 35 to 45 kDa,monomer, glycosylated |
Purity : | >95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel wasstained with Coomassie blue. |
Endotoxin Level : | Endotoxin Free<1 EU/µg |
Biological Activity : | 5 to 25 ng/mL ED50 |
Specific Activity : | The specificactivity was determined by the dose-dependent stimulation of the proliferationof human TF-1 cells (human erythroleukemic indicator cell line). |
OfficialSymbol : | KITLG |
Gene Name : | KITLG KIT ligand [ Homosapiens ] |
Synonyms : | KITLG; KIT ligand;SF; MGF; SCF; FPH2; KL-1; Kitl; SHEP7; kit-ligand; DKFZp686F2250; kit ligand;c-Kit ligand; steel factor; stem cell factor; OTTHUMP00000242388;OTTHUMP00000242389; OTTHUMP00000242390; mast cell growth factor; familialprogressive hyperpigmentation 2 |
Gene ID : | 4254 |
mRNA Refseq : | NM_000899 |
Protein Refseq : | NP_000890 |
MIM : | 184745 |
UniProt ID : | P21583 |
Chromosome Location : | 12q22 |
Pathway : | C-MYB transcriptionfactor network; Cytokine-cytokine receptor interaction; Hematopoietic celllineage; Kit Receptor Signaling Pathway; Melanogenesis; Pathways in cancer;Regulation of KIT signaling; Signal Transduction; Signaling by SCF-KIT;Signaling events mediated by Stem cell factor receptor (c-Kit) |
Function : | cytokine activity;growth factor activity; protein binding; stem cell factor receptor binding |
Products Types
◆ Recombinant Protein | ||
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Kitl-3698M | Active Recombinant Mouse Kitl Protein | +Inquiry |
KITLG-2921R | Recombinant Rat KITLG Protein, His (Fc)-Avi-tagged | +Inquiry |
KITLG-525H | Recombinant Human KITLG Protein | +Inquiry |
KITLG-4321B | Recombinant Bovine KITLG Protein | +Inquiry |
◆ Lysates | ||
KITLG-571HCL | Recombinant Human KITLG cell lysate | +Inquiry |
KITLG-583MCL | Recombinant Mouse KITLG cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionOverexpression or mutations in KITLG and its receptor have been implicated in various cancers, including gastrointestinal stromal tumors (GISTs), mastocytosis, and certain leukemias.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
Dysregulation or mutations in KITLG have been associated with certain disorders like piebaldism, a genetic condition characterized by unpigmented patches of skin and hair.
Upon binding to c-KIT, KITLG activates the SCF signaling pathways, which include the MAPK, PI3K, and JAK/STAT pathways, influencing cell survival, proliferation, and differentiation.
KITLG binds to the c-KIT receptor, a tyrosine kinase receptor, leading to its dimerization and autophosphorylation, which activates downstream signaling pathways.
Given its role in cell proliferation and differentiation, KITLG has been explored as a therapeutic agent in stem cell transplantation settings, and its pathway is a target in certain cancer treatments.
KITLG and its receptor c-KIT are involved in melanogenesis. Their interaction regulates the proliferation and migration of melanocytes, influencing skin, hair, and eye pigmentation.
Customer Reviews (3)
Write a reviewReliable for immunoprecipitation assay.
No contamination, very clean.
Worked perfectly in Western.
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