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Recombinant Pig Plasminogen Activator, Tissue

Cat. No.: PLAT-1293P
Product Overview: Recombinant activepig PLAT that is >95% active.
Description: Tissue plasminogenactivator (abbreviated tPA or PLAT) is a protein involved in the breakdown ofblood clots. It is a serine protease found on endothelial cells, the cellsthat line the blood vessels. As an enzyme, it catalyzes the conversion ofplasminogen to plasmin, the major enzyme responsible for clot breakdown.Because it works on the clotting system, PLATis used in clinical medicine to treat only embolic or thrombotic stroke. Useis contraindicated in hemorrhagic stroke and head trauma.
Source: Insect cell culture
Species: Pig
Form: Frozen liquid in 0.4M HEPES Buffer + 0.1 M NaCl, pH 7.4
Molecular Weight: 70.0 kDa
Concentration: 1.0mg/ml
Purity: >95% by SDS-PAGEanalysis
Endotoxin Level: < 0.1 ng/µg ofprotein
Storage: Store at -80°C. Stablefor 3 years from delivery. Avoid repeated freeze-thaw cycles.
OfficialSymbol: PLAT
Gene Name: PLAT plasminogen activator,tissue [ Sus scrofa ]
Synonyms: PLAT; plasminogenactivator, tissue; tissue-type plasminogen activator; tPA; t-PA;T-plasminogen activator; EC 3.4.21.68
Gene ID: 397121
mRNA Refseq: NM_214054
Protein Refseq: NP_999219
UniProt ID: Q8SQ23
Chromosome Location: 17; 17
Pathway: Complement andcoagulation cascades
Function: peptidase activity;protein binding; serine-type endopeptidase activity

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