| Cat. No. : | Plat-5462R |
| Product Overview : | Recombinant Rat Platand > 85% single chain, > 95% active. |
| Description : | Tissue plasminogenactivator (abbreviated tPA or Plat) is a protein involved in the breakdown ofblood clots. It is a serine protease found on endothelial cells, the cellsthat line the blood vessels. As an enzyme, it catalyzes the conversion ofplasminogen to plasmin, the major enzyme responsible for clot breakdown.Because it works on the clotting system, Platis used in clinical medicine to treat only embolic or thrombotic stroke. Useis contraindicated in hemorrhagic stroke and head trauma. |
| Source : | Insect cells |
| Species : | Rat |
| Form : | Liquid in 0.4 MHEPES + 0.1 M NaCl, pH 7.4 |
| Molecular Weight : | 70.0 kDa |
| Concentration : | 2.0 mg/ml |
| Storage : | Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles. |
| OfficialSymbol : | Plat |
| PDB rendering basedon 1a5h. : |
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| Gene Name : | Plat plasminogen activator,tissue [ Rattus norvegicus ] |
| Synonyms : | Plat; plasminogenactivator, tissue; tPA; PATISS; tissue-type plasminogen activator; t-PA;t-plasminogen activator; tissue plasminogen activator; EC 3.4.21.68 |
| Gene ID : | 25692 |
| mRNA Refseq : | NM_013151 |
| Protein Refseq : | NP_037283 |
| UniProt ID : | P19637 |
| Chromosome Location : | 16q12.5 |
| Pathway : | Blood ClottingCascade; Complement and Coagulation Cascades; Dissolution of Fibrin Clot;Endochondral Ossification; Hemostasis; Senescence and Autophagy; SignalTransduction; Signaling by PDGF |
| Function : | Molecular function;peptidase activity; serine-type endopeptidase activity |
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