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Recombinant Human Heat Shock Protein 90kDa Alpha (cytosolic), Class A Member 1, His-tagged

Cat.No. : HSP90AA1-135H
Product Overview : Recombinant human HSP90AA1was expressed in E. coli.
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Cat. No. : HSP90AA1-135H
Description : HSP90AA1 has beenidentified in the cytosol, nucleus and endoplasmic reticulum, and is reportedto exist in many tissue types. In several tissues, including smooth muscle,HSP-90 comprises up to 2% of total cellular protein. HSP90 functions as adimer, assembled as part of heterocomplex. It possesses ATP-binding site andlow ATPase activity.
Source : E. coli
Species : Human
Form : The protein (1mg/ml) contains 20 mM Tris-HCl, pH 7.4 + 100 mM NaCl.
Purity : Greater than 95.0%as determined by analysis by RP-HPLC and by analysis by reducing andnon-reducing SDS-PAGE Coomassie.
Storage : Store at 2-4°C ifentire vial will be used within 2-4 weeks. Store, frozen at -20°C for longerperiods of time. For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
OfficialSymbol : HSP90AA1
Gene Name : HSP90AA1 heat shock protein90kDa alpha (cytosolic), class A member 1 [ Homo sapiens ]
Synonyms : HSP90AA1; heat shockprotein 90kDa alpha (cytosolic), class A member 1; HSPN; LAP2; HSP86;HSPC1; HSPCA; Hsp89; Hsp90; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4;FLJ31884; heat shock protein HSP 90-alpha; HSP 86; heat shock 86 kDa; OTTHUMP00000246766;OTTHUMP00000246767; heat shock 90kD protein 1, alpha; heat shock 90kDaprotein 1, alpha; renal carcinoma antigen NY-REN-38; heat shock 90kD protein,alpha-like 4; heat shock 90kD protein 1, alpha-like 4
Gene ID : 3320
mRNA Refseq : NM_005348
Protein Refseq : NP_005339
MIM : 140571
UniProt ID : Q86SX1
Chromosome Location : 14q32.33
Pathway : Antigen processingand presentation; Axon guidance; Cell Cycle; Centrosome maturation; Class IPI3K signaling events; Developmental Biology; EBV LMP1 signaling; ErbBreceptor signaling network; Glucocorticoid receptor regulatory network; IL-2Signaling Pathway; Integrins in angiogenesis; Metabolism of nitric oxide;NOD-like receptor signaling pathway; Progesterone-mediated oocyte maturation
Function : ATP binding; ATPaseactivity; TPR domain binding; identical protein binding; nitric-oxidesynthase regulator activity; nucleotide binding; protein binding; proteinhomodimerization activity; protein serine/threonine kinase activity; unfoldedprotein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the relationship between HSP90AA1 protein and inflammatory diseases? 12/08/2019

HSP90AA1 proteins can participate in regulating the expression and function of inflammatory factors in the inflammatory process, which has an impact on the occurrence and development of inflammatory diseases.

What is the role of HSP90AA1 protein in immunotherapy? 10/12/2019

HSP90AA1 proteins can help immune cells fold and activate some important antigens, participate in the immune response process, and have an impact on tumor immunotherapy.

Which fuction of HSP90AA1 protein in tumor diagnosis? 04/18/2019

The expression level of HSP90AA1 protein is upregulated in some tumor cells and can serve as a potential tumor biomarker for tumor diagnosis and monitoring.

Can HSP90AA1 protein be used as a therapeutic target for inflammatory diseases? 04/08/2019

There is no clear evidence that HSP90AA1 protein can be used as a therapeutic target for inflammatory diseases, but its regulatory role in the inflammatory process may provide new ideas for the development of related therapeutic strategies.

What is the relationship between HSP90AA1 protein and tumor drug resistance? 04/04/2019

HSP90AA1 proteins can lead to the occurrence and development of tumor drug resistance by stabilizing and protecting some resistance-related proteins, such as ABC transporters.

How to use HSP90AA1 protein to develop cancer therapeutics? 01/04/2019

Inhibitors targeting HSP90AA1 proteins can be developed to interfere with their interactions with other proteins, affecting the growth and survival of tumor cells.

Customer Reviews (3)

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04/03/2022

    This powerful biological activity of the protein combined with its high purity makes the experimental results extremely reliable.

    02/10/2020

      Application range of this protein is really wide, from the laboratory to the clinic, can see its figure, it is really rare.

      08/08/2019

        Short half-life and high clearance of recombinant proteins enable them to effectively avoid drug accumulation and side effects, and provide a strong guarantee for patient safety.

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