Recombinant Human Heat Shock Protein 90kDa Alpha (cytosolic), Class A Member 1, His-tagged
Cat.No. : | HSP90AA1-135H |
Product Overview : | Recombinant human HSP90AA1was expressed in E. coli. |
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Cat. No. : | HSP90AA1-135H |
Description : | HSP90AA1 has beenidentified in the cytosol, nucleus and endoplasmic reticulum, and is reportedto exist in many tissue types. In several tissues, including smooth muscle,HSP-90 comprises up to 2% of total cellular protein. HSP90 functions as adimer, assembled as part of heterocomplex. It possesses ATP-binding site andlow ATPase activity. |
Source : | E. coli |
Species : | Human |
Form : | The protein (1mg/ml) contains 20 mM Tris-HCl, pH 7.4 + 100 mM NaCl. |
Purity : | Greater than 95.0%as determined by analysis by RP-HPLC and by analysis by reducing andnon-reducing SDS-PAGE Coomassie. |
Storage : | Store at 2-4°C ifentire vial will be used within 2-4 weeks. Store, frozen at -20°C for longerperiods of time. For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA). Please avoid freeze-thaw cycles. |
OfficialSymbol : | HSP90AA1 |
Gene Name : | HSP90AA1 heat shock protein90kDa alpha (cytosolic), class A member 1 [ Homo sapiens ] |
Synonyms : | HSP90AA1; heat shockprotein 90kDa alpha (cytosolic), class A member 1; HSPN; LAP2; HSP86;HSPC1; HSPCA; Hsp89; Hsp90; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4;FLJ31884; heat shock protein HSP 90-alpha; HSP 86; heat shock 86 kDa; OTTHUMP00000246766;OTTHUMP00000246767; heat shock 90kD protein 1, alpha; heat shock 90kDaprotein 1, alpha; renal carcinoma antigen NY-REN-38; heat shock 90kD protein,alpha-like 4; heat shock 90kD protein 1, alpha-like 4 |
Gene ID : | 3320 |
mRNA Refseq : | NM_005348 |
Protein Refseq : | NP_005339 |
MIM : | 140571 |
UniProt ID : | Q86SX1 |
Chromosome Location : | 14q32.33 |
Pathway : | Antigen processingand presentation; Axon guidance; Cell Cycle; Centrosome maturation; Class IPI3K signaling events; Developmental Biology; EBV LMP1 signaling; ErbBreceptor signaling network; Glucocorticoid receptor regulatory network; IL-2Signaling Pathway; Integrins in angiogenesis; Metabolism of nitric oxide;NOD-like receptor signaling pathway; Progesterone-mediated oocyte maturation |
Function : | ATP binding; ATPaseactivity; TPR domain binding; identical protein binding; nitric-oxidesynthase regulator activity; nucleotide binding; protein binding; proteinhomodimerization activity; protein serine/threonine kinase activity; unfoldedprotein binding |
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◆ Native Protein | ||
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◆ Lysates | ||
HSP90AA1-5362HCL | Recombinant Human HSP90AA1 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionHSP90AA1 proteins can participate in regulating the expression and function of inflammatory factors in the inflammatory process, which has an impact on the occurrence and development of inflammatory diseases.
HSP90AA1 proteins can help immune cells fold and activate some important antigens, participate in the immune response process, and have an impact on tumor immunotherapy.
The expression level of HSP90AA1 protein is upregulated in some tumor cells and can serve as a potential tumor biomarker for tumor diagnosis and monitoring.
There is no clear evidence that HSP90AA1 protein can be used as a therapeutic target for inflammatory diseases, but its regulatory role in the inflammatory process may provide new ideas for the development of related therapeutic strategies.
HSP90AA1 proteins can lead to the occurrence and development of tumor drug resistance by stabilizing and protecting some resistance-related proteins, such as ABC transporters.
Inhibitors targeting HSP90AA1 proteins can be developed to interfere with their interactions with other proteins, affecting the growth and survival of tumor cells.
Customer Reviews (3)
Write a reviewThis powerful biological activity of the protein combined with its high purity makes the experimental results extremely reliable.
Application range of this protein is really wide, from the laboratory to the clinic, can see its figure, it is really rare.
Short half-life and high clearance of recombinant proteins enable them to effectively avoid drug accumulation and side effects, and provide a strong guarantee for patient safety.
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