Recombinant Human Nuclear Receptor Corepressor 2, GST-tagged NCOR2-1889H

Specification Gene Information Related Products

Cat. No. :	NCOR2-1889H
Product Overview :	Recombinant humanNCOR2 DAD domain (amino acids 395-489) with N-terminal GST tag.
Description :	NCOR2 are transcriptional corepresoors thatplay an essential role in the regulation of development and metabolism. Theinteraction of HDAC3 with the deacetylase activation domain (DAD) of NCOR2 isrequired for activation of the otherwise inert deacetylase.
Source :	E. coli
Species :	Human
Form :	Liquid in 50 mMTris-HCl, pH 8.0 + 138 mM NaCl +20 mM glutathione +10% glycerol.
Molecular Weight :	39 kDa
Applications :	Enzymekinetics; Screening inhibitors; Selectivity profiling. The optimal antibodyconcentration should be determined for each specific application.
storage :	Stablefor 6 months in working aliquots at -80°C. Avoidrepeated freeze-thaw cycles.
OfficialSymbol :	NCOR2
Pathways :	Adipogenesis; Androgen Receptor SignalingPathway; Delta-Notch Signaling Pathway; Developmental Biology; Fatty acidtriacylglycerol; Metabolism of lipids and lipoproteins; Notch signalingpathway; Notch-mediated HES/HEY network; RXR and RAR heterodimerization withother nuclear receptor; Regulation of Lipid Metabolism by Peroxisomeproliferator-activated receptor alpha (PPARalpha); Retinoic acid receptors-mediated signaling

Gene Name :	NCOR2 nuclear receptorcorepressor 2 [ Homo sapiens ]
Synonyms :	NCOR2; nuclearreceptor corepressor 2; SMRT; TRAC; CTG26;SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; FLJ25011; SMRTE-tau; nuclearreceptor corepressor 2; OTTHUMP00000197398; OTTHUMP00000197399;OTTHUMP00000197400; OTTHUMP00000197402; CTG repeat protein 26; T3receptor-associating factor; thyroid-, retinoic-acid-receptor-associatedcorepressor; silencing mediator for retinoid and thyroid hormone receptors
Gene ID :	9612
mRNA Refseq :	NM_006312
Protein Refseq :	NP_006303
MIM :	600848
UniProt ID :	Q9BT61
Chromosome Location :	12q24
Function :	Notch binding; chromatin binding; histonedeacetylase binding; protein N-terminus binding; protein binding; sequence-specificDNA binding; transcription corepressor activity