| Cat. No.: | NCOR2-1889H |
| Product Overview: | Recombinant humanNCOR2 DAD domain (amino acids 395-489) with N-terminal GST tag. |
| Description: | NCOR2 are transcriptional corepresoors thatplay an essential role in the regulation of development and metabolism. Theinteraction of HDAC3 with the deacetylase activation domain (DAD) of NCOR2 isrequired for activation of the otherwise inert deacetylase. |
| Source: | E. coli |
| Species: | Human |
| Form: | Liquid in 50 mMTris-HCl, pH 8.0 + 138 mM NaCl +20 mM glutathione +10% glycerol. |
| Molecular Weight: | 39 kDa |
| Applications: | Enzymekinetics; Screening inhibitors; Selectivity profiling. The optimal antibodyconcentration should be determined for each specific application. |
| storage: | Stablefor 6 months in working aliquots at -80°C. Avoidrepeated freeze-thaw cycles. |
| OfficialSymbol: | NCOR2 |
| Pathways: | Adipogenesis; Androgen Receptor SignalingPathway; Delta-Notch Signaling Pathway; Developmental Biology; Fatty acidtriacylglycerol; Metabolism of lipids and lipoproteins; Notch signalingpathway; Notch-mediated HES/HEY network; RXR and RAR heterodimerization withother nuclear receptor; Regulation of Lipid Metabolism by Peroxisomeproliferator-activated receptor alpha (PPARalpha); Retinoic acid receptors-mediated signaling |
| Gene Name: | NCOR2 nuclear receptorcorepressor 2 [ Homo sapiens ] |
| Synonyms: | NCOR2; nuclearreceptor corepressor 2; SMRT; TRAC; CTG26;SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; FLJ25011; SMRTE-tau; nuclearreceptor corepressor 2; OTTHUMP00000197398; OTTHUMP00000197399;OTTHUMP00000197400; OTTHUMP00000197402; CTG repeat protein 26; T3receptor-associating factor; thyroid-, retinoic-acid-receptor-associatedcorepressor; silencing mediator for retinoid and thyroid hormone receptors |
| Gene ID: | 9612 |
| mRNA Refseq: | NM_006312 |
| Protein Refseq: | NP_006303 |
| MIM: | 600848 |
| UniProt ID: | Q9BT61 |
| Chromosome Location: | 12q24 |
| Function: | Notch binding; chromatin binding; histonedeacetylase binding; protein N-terminus binding; protein binding; sequence-specificDNA binding; transcription corepressor activity |
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