| Cat. No. : |
H60a-5636M |
| Description : |
H60a wasoriginally described as an immunodominant histocompatibility antigen that isexpressed in BALB mice but not in B6 mice. More recently it was reported to functionas a ligand for mouse NKG2D, an activating receptor found on NK cells, onsome T cell subsets, and on stimulated macrophages. H60a shares approximately25 percent amino acid identity with the Rae-1 family, a small group ofproteins that also function as ligands for mouse NKG2D. H60a and the Rae-1proteins are distantly related to MHC class I proteins, but they possessesonly the α1 and α2 Ig-like domains, and have no capacity to bind peptide orinteract with β2-microglobulin. |
| Source : |
Mammalian cells |
| Form : |
Lyophilizedfrom a 0.2 um filtered solution in PBS. |
| N-terminalSequence : |
Asp30 |
| MolecularWeight : |
47.8 kDa (monomer) |
| Activity : |
Measuredby its ability to bind to immobilized rmNKG2D/Fc Chimera in a functionalELISA. |
| Endotoxin Level : |
<1.0EU per 1μg of the protein by the LAL method. |
| SDS-PAGE : |
75-90kDa, reducing conditions. |
| Purity : |
>95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
| Reconstitution : |
100 μg/mLin sterile PBS |
| Storage : |
Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution. |
