Active Recombinant Mouse Insulin-Like Growth Factor Binding Protein 1

• Cat.No.: Igfbp1-5643M
• Product Overview: RecombinantMouse Igfbp1 protein was expressed in Murine myeloma cellline. Ala26-Asn272.

Specification

• Cat. No.: Igfbp1-5643M
• Description: Theinsulin-like growth factor binding protein (IGFBP) family consists of six structurallyrelated proteins that bind IGF with high affinity. These proteins share conservedcysteine-rich N- and C-terminal regions that participate in IGF binding.IGFBPs regulate the bioavailability of IGFs and modulate their biologicalactivities, both positively and negatively. Some IGFBPs also have intrinsicbioactivity that is IGF-independent. Post-transitional modifications of theIGFBPs, including glycosylation, phosphorylation and proteolysis, influenceIGF binding affinities and tissue localization, affecting both theIGF-dependent and independent functions.
• Source: Mammalian cells
• Form: Suppliedas a 0.2 um filtered solution in Acetonitrile and TFA.
• N-terminalSequence: Ala26
• MolecularWeight: 27 kDa
• Activity: Measuredby its ability to inhibit the biological activity of IGF-I or IGF-II on MCF-7human breast adenocarcinoma cells. The ED50 for this effect is typically 3-15μg/mL in the presence of 5 ng/mL rmIGF-I.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 34 kDa,reducing conditions.
• Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 1month, 2 to 8 °C under sterile conditions after opening.

Gene Information

• Gene Name: Igfbp1 insulin-like growthfactor binding protein 1 [ Mus musculus ]
• Official Symbol: Igfbp1
• Synonyms: Igfbp1; insulin-likegrowth factor binding protein 1; insulin-like growth factor-bindingprotein 1; IBP-1; IGF-binding protein 1; INSULIN-LIKE GROWTH FACTOR BINDINGPROTEIN 1 PRECURSOR (IGFBP-1) (IBP-1) (IGF-BINDING PROTEIN 1); IGFBP-1; Igfbp-1
• Gene ID: 16006
• mRNA Refseq: NM_008341
• Protein Refseq: NP_032367
• UniProt ID: P47876
• Chromosome Location: 11
• Pathway: Diabetes pathways;Disease; Myometrial Relaxation and Contraction Pathways; Regulation ofInsulin-like Growth Factor (IGF) Activity by Insulin-like Growth FactorBinding Proteins (IGFBPs)
• Function: growth factorbinding; insulin-like growth factor binding