Active Recombinant Mouse Jagged 2, Fc-tagged
Cat.No. : | Jag2-5666M |
Product Overview : | RecombinantMouse Jag2 protein was expressed in Murine myeloma cell line with theFc part of Mouse IgG2A Glu98-Lys330 (C-terminus) and Mouse Jag2 Met27-Lys1084(N-terminus). |
- Specification
- Gene Information
- Related Products
Cat. No. : | Jag2-5666M |
Description : | MouseJag2 is a 150 kDa member of the Delta-Serrate-Lag-2 (DSL) family of ligandsthat activate LIN12/Notch proteins, and thereby regulate cell fatedeterminations during development. It is a type 1 transmembrane protein thatis synthesized as a 1247 amino acid (aa) precursor. It contains a 23 aa signalsequence, a large, 1059 aa extracellular region, a 21 aa transmembraneregion, and a short, 144 aa cytoplasmic region. The extracellular regioncontains four potential N-linked glycosylation sites, a DSL domain, 16EGF-like repeats, many of which are also sites of calcium binding, and acysteine-rich region just proximal to the transmembrane segment. |
Source : | Mammalian cells |
Form : | Lyophilizedfrom a 0.2 μm filtered solution in PBS and EDTA. |
N-terminalSequence : | Met27 |
MolecularWeight : | 140.8 kDa (monomer) |
Activity : | Measuredby the ability of immobilized protein to enhance BMP-2 induced alkalinephosphatase activity in C3H10T1/2 mouse cells. The ED50 for this effect istypically 0.3-1.2 μg/mL. Measured by its ability to bind rrNotch-1 in afunctional ELISA. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 160-165kDa, reducing conditions. |
Purity : | >90%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | 100 μg/mLin sterile PBS |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution. |
Gene Name : | Jag2 jagged 2 [ Mus musculus] |
Official Symbol : | Jag2 |
Synonyms : | Jag2; jagged 2; sm; Serh;D12Ggc2e; mJagged2-1; protein jagged-2; syndactylism |
Gene ID : | 16450 |
mRNA Refseq : | NM_010588 |
Protein Refseq : | NP_034718 |
UniProt ID : | Q9QYE5 |
Chromosome Location : | 12 |
Pathway : | Delta-NotchSignaling Pathway; Notch Signaling Pathway; Notch receptor binds with aligand; Notch signaling pathway; Receptor-ligand binding initiates the secondproteolytic cleavage of Notch receptor; Signal Transduction; Signaling byNotch |
Function : | Notch binding;growth factor activity |
Products Types
◆ Recombinant Protein | ||
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Jag2-79M | Recombinant Mouse Jag2 Protein, His (Fc)-Avi-tagged | +Inquiry |
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JAG2-1869H | Recombinant Human JAG2 protein, His-tagged | +Inquiry |
Jag2-383M | Recombinant Mouse Jag2, Fc-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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