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Recombinant Mouse Jagged 2, Fc-tagged

Cat. No.: Jag2-5666M
Product Overview: RecombinantMouse Jag2 protein was expressed in Murine myeloma cell line with theFc part of Mouse IgG2A Glu98-Lys330 (C-terminus) and Mouse Jag2 Met27-Lys1084(N-terminus).
Description: MouseJag2 is a 150 kDa member of the Delta-Serrate-Lag-2 (DSL) family of ligandsthat activate LIN12/Notch proteins, and thereby regulate cell fatedeterminations during development. It is a type 1 transmembrane protein thatis synthesized as a 1247 amino acid (aa) precursor. It contains a 23 aa signalsequence, a large, 1059 aa extracellular region, a 21 aa transmembraneregion, and a short, 144 aa cytoplasmic region. The extracellular regioncontains four potential N-linked glycosylation sites, a DSL domain, 16EGF-like repeats, many of which are also sites of calcium binding, and acysteine-rich region just proximal to the transmembrane segment.
Source: Murine myeloma cellline, NS0-derived.
Form: Lyophilizedfrom a 0.2 μm filtered solution in PBS and EDTA.
N-terminalSequence: Met27
MolecularWeight: 140.8 kDa (monomer)
Activity: Measuredby the ability of immobilized protein to enhance BMP-2 induced alkalinephosphatase activity in C3H10T1/2 mouse cells. The ED50 for this effect istypically 0.3-1.2 μg/mL. Measured by its ability to bind rrNotch-1 in afunctional ELISA.
Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE: 160-165kDa, reducing conditions.
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: 100 μg/mLin sterile PBS
Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Gene Name: Jag2 jagged 2 [ Mus musculus]
Official Symbol: Jag2
Synonyms: Jag2; jagged 2; sm; Serh;D12Ggc2e; mJagged2-1; protein jagged-2; syndactylism
Gene ID: 16450
mRNA Refseq: NM_010588
Protein Refseq: NP_034718
UniProt ID: Q9QYE5
Chromosome Location: 12
Pathway: Delta-NotchSignaling Pathway; Notch Signaling Pathway; Notch receptor binds with aligand; Notch signaling pathway; Receptor-ligand binding initiates the secondproteolytic cleavage of Notch receptor; Signal Transduction; Signaling byNotch
Function: Notch binding;growth factor activity

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