Active Recombinant Human Growth Differentiation Factor 1
Cat.No. : | GDF1-717H |
Product Overview : | Recombinant Human GDF1protein was expressed in CHO. Asp254-Arg372. |
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Cat. No. : | GDF1-717H |
Description : | GDF1 is a 12-15 kDasecreted protein in the TGFβ superfamily. It is the functional equivalent offrog, zebrafish, and chick Vg1. Human GDF1 is synthesized as a preproproteinthat contains a 29 amino acid (aa) signal peptide, a 224 aa propeptide, and a119 aa mature peptide which is released following proteolysis at a dibasic cleavagesite. Mature human GDF1 shares 81% aa sequence identity with mouse and ratGDF1. GDF1 is expressed in the developing and adult nervous system,particularly in neurons of the cerebral cortex and hippocampus. |
Source : | Chinese HamsterOvary cell line, CHO-derived. |
Form : | Lyophilized from a0.2 μm filtered solution in HCl with BSA as a carrier protein. |
N-terminalSequence : | Asp254 |
Molecular Weight : | 12.6 kDa |
Activity : | Measuredby its ability to induce Smad2 phosphorylation in P19 mouse embryonalcarcinoma cells. Mazerbourg, S. et al. (2004) Mol. Endocrinol. 18:653. 50ng/mL of Recombinant Human GDF1 can effectively induce Smad2 phosphorylation. |
Endotoxin Level : | <1.0 EUper 1 μg of the protein by the LAL method. |
SDS-PAGE : | 13 kDa,reducing conditions. |
Purity : | >95%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | 100μg/mL in 4 mM HCl that containing at least 0.1% human or bovine serum albumin. |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution. |
Gene Name : | GDF1 growth differentiationfactor 1 [ Homo sapiens ] |
Official Symbol : | GDF1 |
Synonyms : | GDF1; growthdifferentiation factor 1; DORV; DTGA3; embryonic growth/differentiationfactor 1; GDF-1 |
Gene ID : | 2657 |
mRNA Refseq : | NM_001492 |
Protein Refseq : | NP_001483 |
MIM : | 602880 |
UniProt ID : | P27539 |
Chromosome Location : | 19p13.11 |
Pathway : | Developmental Biology; Signaling by NODAL |
Function : | cytokine activity; growth factor activity |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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