Active Recombinant Mouse Insulin-Like Growth Factor 2

• Cat.No.: Igf2-736M
• Product Overview: Recombinant Mouse Igf2protein was expressed in E. coli. Ala25-Glu91.

Specification

• Cat. No.: Igf2-736M
• Description: Igf2 is a secreted 8kDa polypeptide that belongs to the insulin family of peptide growth factors.It is part of a complex system of growth and metabolic-regulating proteinsthat is particularly important during development. It has been associatedwith nervous system proliferation and differentiation, myelination, adrenalcortical proliferation, and skeletal growth and differentiation.
• Source: E. coli-derived.
• Form: Lyophilized from a0.2 μm filtered solution in Acetonitrile and TFA.
• N-terminalSequence: Ala25
• Molecular Weight: 7.4 kDa
• Activity: Measuredin a serum-free cell proliferation assay using MCF7 human breastadenocarcinoma cells. Karey, K.P. et al. (1988) Cancer Research 48:4083. TheED50 for this effect is typically 2-10 ng/mL.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• Purity: >97%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 100 μg/ mLin sterile PBS
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.

Gene Information

• Gene Name: Igf2 insulin-like growth factor2 [ Mus musculus ]
• Official Symbol: Igf2
• Synonyms: Igf2; insulin-likegrowth factor 2; Mpr; M6pr; Peg2; Igf-2; Igf-II; AL033362;multiplication-stimulating polypeptide
• Gene ID: 16002
• mRNA Refseq: NM_001122736
• Protein Refseq: NP_001116208
• UniProt ID: P09535
• Chromosome Location: 7 F5; 7 69.09 cM
• Pathway: Apoptosis; Diabetespathways; Disease; Endochondral Ossification; Hedgehog Signaling Pathway;PI3K/Akt/mTOR signaling pathway; Regulation of Insulin-like Growth Factor(IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
• Function: growth factoractivity; hormone activity; insulin receptor binding; insulin-like growthfactor receptor binding; protein binding; protein serine/threonine kinaseactivator activity; receptor activator activity