"BMP1" Related Products

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Recombinant Human Bone Morphogenetic Protein 1, His-tagged

Cat. No. : BMP1-571H
Product Overview : Recombinant Human BMP1protein was expressed in Murine myeloma cell line with a C-terminal 6-His tag.Ala121-Gln730.
Description : Bone morphogeneticprotein 1 (BMP1), also known as procollagen Cproteinase (PCP), is a zinc proteaseof the astacin family. BMP1/PCP plays a key role in formation ofextracellular matrix (ECM) by converting precursor proteins into their matureand functional forms. The precursor proteins identified as substrates forBMP1/PCP include collagens, biglycan, laminin 5, dentin matrix protein1, andlysyl oxidase. There are six alternatively spliced forms known to be derivedfrom the BMP1 gene, and isoform 1 consisting of residues 1 to 730 wasexpressed.
Source : Murine myeloma cellline, NS0-derived.
Form : Lyophilized from a0.2 μm filtered solution in HEPES, NaCl, CaCl2, ZnCl2and Brij-35.
N-terminalSequence : Ala121
Molecular Weight : 70.5 kDa
Activity : Measured by itsability to cleave a fluorogenic peptide substrate, Mca-YVADAPK (Dnp)-OH. Thespecific activity is > 4 pmol/min/μg, as measured under the describedconditions.
Endotoxin Level : < 1.0EU per 1 μg of the protein by the LAL method.
SDS-PAGE : 84 kDa, reducingconditions.
Purity : > 95%, by SDSPAGEunder reducing conditions and visualized by silver stain.
Reconstitution : 100 μg/mL in sterile25 mM HEPES and 0.01% Brij-35, pH 7.5.
Storage : Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt,-20 to -70°C as supplied. 3 months, -20 to -70°C under sterile conditionsafter reconstitution.
PDB rendering basedon 3edg. :

Gene Name : BMP1 bone morphogenetic protein 1[ Homo sapiens ]
Official Symbol : BMP1
Synonyms : BMP1; bonemorphogenetic protein 1; procollagen C-proteinase; mammalian tolloid protein;procollagen C-endopeptidase; BMP-1; PCP; PCOLC; mTId; EC 3.4.24.19
Gene ID : 649
mRNA Refseq : NM_001199
Protein Refseq : NP_001190
MIM : 112264
UniProt ID : P13497
Chromosome Location : 8p21
Pathway : Adipogenesis;HDL-mediated lipid transport; Lipid digestion; Lipoprotein metabolism;Metabolism; Metabolism of lipids and lipoproteins
Function : calcium ion binding;cytokine activity; growth factor activity; metal ion binding;metalloendopeptidase activity; metallopeptidase activity; peptidase activity;zinc ion binding

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