Active Recombinant Human Fucosyltransferase 8 (alpha (1, 6) fucosyltransferase), His-tagged
Cat.No. : | FUT8-577H |
Product Overview : | Recombinanthuman FUT8 protein was expressed in Chinese Hamster Ovary cell line, CHO-derived;with an N-terminus human CD33 signal sequence, and 6-His tag. Asp32-Lys575. |
- Specification
- Gene Information
- Related Products
Cat. No. : | FUT8-577H |
Description : | FUT8 is frequentlyfound at terminal sites on various glycols and is essential for thegeneration of many sugar epitomes. Well known FUT8 containing glycols includeLewis and ABO blood group antigens. Lewis epitomes are key elements involvedin leukocyte homing and extravasations process, thus are essential forlymphocyte maturation and natural defense functions. |
Source : | Chinese HamsterOvary cell line, CHO-derived |
Form : | Supplied as a 0.2 μmfiltered solution in Tris and NaCl. |
N-terminal Sequence : | His |
Molecular Weight : | 64 kDa |
Activity : | Measured by itsability to hydrolyze the donor substrate GDP-fucose. The specific activity is> 0.75 pmole/min/μg, as measured under the described conditions. |
Endotoxin Level : | <1.0 EU per 1 μgof the protein by the LAL method. |
SDS-PAGE : | 58-62 kDa, reducingconditions |
Purity : | >90%, by SDS-PAGEunder reducing conditions and visualized by Colloidal Coomassie Blue stain at5 μg per lane. |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3months, -20 to -70 °C under sterile conditions after reconstitution. |
Gene Name : | FUT8 fucosyltransferase 8 (alpha(1, 6) fucosyltransferase) [ Homo sapiens ] |
Official Symbol : | FUT8 |
Synonyms : | FUT8; fucosyltransferase8 (alpha (1, 6) fucosyltransferase); alpha-(1, 6)-fucosyltransferase;OTTHUMP00000245300; OTTHUMP00000245301; OTTHUMP00000245302; OTTHUMP00000245303;OTTHUMP00000245304; OTTHUMP00000245305; OTTHUMP00000245306; OTTHUMP00000245307;OTTHUMP00000183477; OTTHUMP00000183478; OTTHUMP00000245299; EC 2.4.1.68; Fucosyltransferase8; GDP-L-Fuc: N-acetyl-beta-D-glucosaminide alpha 1, 6-fucosyltransferase;GDP-fucose-glycoprotein fucosyltransferase; Glycoprotein; 6-alpha-L-fucosyltransferase;alpha1-6FucT; MGC26465 |
Gene ID : | 2530 |
mRNA Refseq : | NM_004480 |
Protein Refseq : | NP_004471 |
MIM : | 602589 |
UniProt ID : | Q9BYC5 |
Chromosome Location : | 14q24.3 |
Pathway : | AsparagineN-linked glycosylation; Glycosaminoglycan biosynthesis-keratan sulfate;Metabolic pathways; Metabolism of proteins; N-Glycanbiosynthesis; N-glycan antennae elongation in the medial/trans-Golgi;N-glycan biosynthesis, complex type; N-glycan biosynthesis, complex type;Reactions specific to the complex N-glycan synthesis pathway; Transcriptionalmisregulation in cancer; Transport to the Golgi and subsequent modification |
Function : | SH3domain binding; glycoprotein 6-alpha-L-fucosyltransferase activity;transferase activity, transferring glycosyl groups |
Products Types
◆ Recombinant Protein | ||
FUT8-3394M | Recombinant Mouse FUT8 Protein, His (Fc)-Avi-tagged | +Inquiry |
FUT8-2071R | Recombinant Rat FUT8 Protein, His (Fc)-Avi-tagged | +Inquiry |
FUT8-2659H | Recombinant Human FUT8 Protein, MYC/DDK-tagged | +Inquiry |
FUT8-1590R | Recombinant Rhesus Macaque FUT8 Protein, His (Fc)-Avi-tagged | +Inquiry |
FUT8-31H | Active Recombinant Human FUT8 Protein (AA 41-575), N-6×His/GFP tagged | +Inquiry |
◆ Lysates | ||
FUT8-497HCL | Recombinant Human FUT8 cell lysate | +Inquiry |
FUT8-001HCL | Recombinant Hamster FUT8 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionYes, altering FUT8 activity can impact cancer cell growth and metastasis, making it a potential target for cancer therapies.
One challenge is the specificity of FUT8 inhibitors, ensuring they do not affect other essential glycosylation processes in the body.
Yes, abnormal glycosylation patterns due to FUT8 alterations can serve as biomarkers for diseases like cancer, aiding in early diagnosis.
FUT8-mediated glycosylation of antibodies can enhance their stability and effector functions, making them more effective in treating diseases like cancer and autoimmune disorders.
Yes, deficiencies in FUT8 have been associated with certain types of cancers and developmental disorders.
Customer Reviews (3)
Write a reviewWith the manufacturer's outstanding technical support, you can be assured that any challenges you encounter will be efficiently addressed.
Researchers who have utilized the FUT8 protein laud its reliability and effectiveness in their studies.
Its superior quality, combined with the manufacturer's exceptional technical support, provides researchers with the confidence they need to conduct successful experiments and obtain meaningful results.
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