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Recombinant Human Frizzled Family Receptor 10, Fc-tagged

Cat. No.: FZD10-581H
Product Overview: RecombinantHuman FZD10 protein was expressed in Murine myeloma cell line with the Fcpart of IgG1 Pro100-Lys330 (C-terminus) and Human Frizzled 10Ile21Gly161 (N-terminus).
Description: FZD10 is a 68 kDa sevenpass transmembrane glycoprotein in the Frizzled family of Wnt receptors. The 205amino acid N-terminal extracellular region of FZD10 contains a cysteine-rich domainthat comprises the Wnt binding domain and mediates receptor oligomerization.
Source: Murine myeloma cellline, NS0-derived
Form: Supplied as a 0.2 μmfiltered solution in PBS.
N-terminal Sequence: Ile21
Molecular Weight: 43 kDa
Activity: Measured by itsbinding ability in a functional ELISA. Biotinylated rmWnt-5a immobilized on astreptavidincoated plate at 1 μg/mL can bind rhFrizzled-10/ Fc Chimera withan apparent Kd < 35 nM.
Endotoxin Level: <1.0 EU per 1 μgof the protein by the LAL method.
SDS-PAGE: 56-58 kDa, reducingconditions
Purity: >90%, by SDS-PAGEunder reducing conditions and visualized by silver stain.
Reconstitution: Reconstitute at 100μg/mL in sterile PBS.
Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to-70 °C under sterile conditions after reconstitution.
Gene Name: FZD10 frizzled family receptor10 [ Homo sapiens ]
Official Symbol: FZD10
Synonyms: FZD10;frizzled family receptor 10; frizzled (Drosophila) homolog 10; frizzled 10,seven transmembrane spanning receptor; frizzled homolog 10 (Drosophila);frizzled-10; CD350; CD 350; CD 350 antigen; FZ10; FZD 10; FzE7; hFz10;frizzled homolog 10; frizzled 10, seven transmembrane spanning receptor;Fz10; FZ-10; OTTHUMP00000238659
Gene ID: 11211
mRNA Refseq: NM_007197
Protein Refseq: NP_009128
MIM: 606147
UniProt ID: Q9ULW2
Chromosome Location: 12q24.33
Pathway: Basal cellcarcinoma; Class B/2 (Secretin family receptors); GPCR ligand binding; HTLV-Iinfection; Melanogenesis; Pathways in cancer; Signal Transduction; Signalingby GPCR; Wnt Signaling Pathway; Wnt signaling network
Function: G-protein coupledreceptor activity; PDZ domain binding; Wnt-activated receptor activity;Wnt-protein binding; protein binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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