Active Recombinant Human Fc Receptor-Like 5, His-tagged

• Cat.No.: FCRL5-506H
• Product Overview: RecombinantHuman FCRL5 protein was expressed in Murine myeloma cellline. Gln16-Arg844,with a C-terminal 6-His tag.

Specification

• Cat. No.: FCRL5-506H
• Description: FCRL5 isa 120 kDa protein with sequence homology to classical Fc receptors. They are differentiallyexpressed within the B cell lineage and can either promote or inhibit B cellproliferation and activation. According to R&D Systems testing, FCRL5binds to purified human IgG with high affinity. Mature human FCRL5 consistsof a 836 amino acid (aa) extracellular domain (ECD) with nine Ig-like domains,a 21 aa transmembrane segment, and a 105 aa cytoplasmic domain with one immunotyrosineactivation motif (ITAM) and two immunotyrosine inhibitory motifs (ITIMs).
• Source: Mammalian cells
• Form: Lyophilized from a0.2 um filtered solution in PBS.
• N-terminalSequence: Gln16 predicted
• MolecularWeight: 91.5 kDa
• Activity: Measuredby its ability to bind human IgG with an estimated KD < 30 nM.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 110-120kDa, reducing conditions.
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstitute at 100μg/mLin PBS.
• Storage: Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: FCRL5 Fc receptor-like 5 [ Homosapiens ]
• Official Symbol: FCRL5
• Synonyms: FCRL5;Fc receptor-like 5; Fc receptor-like protein 5; BXMAS1; CD307e; FCRH5; IRTA2;BXMAS1; CD307 antigen; Fc receptor homolog 5; Fc receptor like 5; FcR-likeprotein 5; FCRL5_HUMAN; Immune receptor translocation-associated protein 2;Immunoglobulin receptor translocation associated gene 2 protein;Immunoglobulin superfamily receptor translocation associated gene 2 protein;UNQ503/PRO820; immunoglobulin superfamily receptor translocation associated 2(IRTA2); CD307; PRO820; RP11-217A12.1
• Gene ID: 83416
• mRNA Refseq: NM_001195388
• Protein Refseq: NP_001182317
• MIM: 605877
• UniProt ID: Q96RD9
• Chromosome Location: 1q21
• Function: receptor activity