"INSL3" Related Products

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Recombinant Human Insulin-Like 3 (Leydig cell)

Cat. No. : INSL3-384H
Product Overview : RecombinantHuman INSL3 protein was expressed in E. coli. Ala106-Tyr131(A chain) & Leu21-Ala55.
Description : INSL3 isa member of the insulin/relaxin superfamily. INSL3 is a secreted proteinproduced in high amounts by testicular Leydig cells, and in lower amounts by ovarianfollicular theca interna cells. As with other insulin/relaxin superfamilymembers, human INSL3 is synthesized as a preprohormone. The Prepro INSL3precursor is 131 amino acids (aa) in length. It is processed by a prohormoneconvertase to remove a 20 aa signal sequence and a 47 aa internal pro-, or C-peptidethat separates a 35 aa N-terminal B chain from a 26 aa C-terminal A chain.
Source : E. coli
Form : Lyophilizedfrom a 0.2 um filtered solution in PBS.
N-terminalSequence : Ala106 (A chain)& Leu21(B chain)
MolecularWeight : 2.8 kDa (A chain),3.3 kDa (B chain)
Activity : Measuredby its ability to induce cAMP accumulation in human RXFP2 transfected HEK293human embryonic kidney cells. The ED50 for this effect is typically 12.5-50 pg/mL.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100μg/mL in sterile PBS.
Storage : Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months,-20 to -70°C under sterile conditions after reconstitution.
PDBrendering based on 2h8b. :

Gene Name : INSL3 insulin-like 3 (Leydigcell) [ Homo sapiens ]
Official Symbol : INSL3
Synonyms : INSL3; insulin-like3 (Leydig cell); RLF; RLNL; insulin-like 3; ley-I-L; relaxin-likefactor b; leydig insulin-like peptide; leydig insulin -like hormone
Gene ID : 3640
mRNA Refseq : NM_005543
Protein Refseq : NP_005534
MIM : 146738
UniProt ID : P51460
Chromosome Location : 19p13.2-p12
Pathway : Class A/1 (Rhodopsin-like receptors);Cytokine Signaling in Immune system; G alpha (s) signalling events; GPCRdownstream signaling; GPCR ligand binding; Immune System; Interleukinreceptor SHC signaling; Interleukin-2 signaling; Interleukin-3, 5 and GM-CSFsignaling; Interleukin-7 signaling; Peptide ligand-binding receptors; Relaxinreceptors; Signal Transduction; Signaling by GPCR; Signaling by Interleukins
Function : G-protein coupled receptor binding; hormoneactivity; insulin receptor binding; receptor binding

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