"IL36B" Related Products


Recombinant Mouse Interleukin 1 Family, Member 8

Cat. No.: Il1f8-646M
Product Overview: RecombinantMouse Il1f8 protein was expressed in E. coli. Ser31-Lys183.
Description: Mouse Il1f8 is amember of the IL-1 family of proteins that includes IL-1β, IL-1α, IL-1ra, IL-18,IL-36Ra/IL-1F5, IL-36α/IL-1F6, IL-37/IL-1F7, IL-36γ/IL-1F9 and IL-1F10. Allfamily members show a 12 β-stranded β-trefoil configuration, share up to 50%amino acid (aa) sequence identity, and are believed to have arisen from a commonancestral gene. Although two alternatively spliced transcript variants forhuman Il1f8 havebeen described, to date, only one mouse Il1f8 isoformis known. Mouse Il1f8 is synthesized as a 183 amino acid (aa)protein that contains no signal sequence, no prosegment and no potential N-linkedglycosylation site(s).
Source: E. coli
Form: Lyophilizedfrom a 0.2 um filtered solution in MES, NaCl, TCEP, EDTA, CHAPS and PEG 8000with BSA as a carrier protein.
N-terminalSequence: Ser31
MolecularWeight: 17.4 kDa
Activity: Measuredby its ability to induce IL-6 secretion by NIH/3T3 mouse embryonic fibroblasts.The ED50 for this effect is typically 1-6 ng/mL.
Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE: 16 kDa,reducing conditions.
Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 100μg/mL in 10 mM TrisHCl, pH 8.0.
Storage: Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: Il1f8 interleukin1 family, member 8 [ Mus musculus ]
Official Symbol: Il1f8
Synonyms: Il1f8; interleukin 1family, member 8; Il36b; 2310043N20Rik; interleukin-36 beta; IL-1F8;interleukin-1 family member 8
Gene ID: 69677
mRNA Refseq: NM_027163
Protein Refseq: NP_081439
UniProt ID: Q08EA6
Chromosome Location: 2
Function: cytokine activity; interleukin-1receptor binding; molecular_function

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