"Fgfr3" Related Products


Recombinant Mouse Fibroblast Growth Factor Receptor 3, Fc-tagged

Cat. No.: Fgfr3-536M
Product Overview: Recombinant Mouse Fgfr3protein was expressed in Murine myeloma cell line with the Fc part of humanIgG1 Pro100-Lys330 (C-terminus) and Ala33-Tyr367 (N-terminus).
Description: Fibroblast growthfactors (FGFs) comprise a family of at least eighteen structurally relatedproteins that are involved in a multitude of physiological and pathologicalcellular processes, including cell growth, differentiation, angiogenesis,wound healing and tumorgenesis. The biological activities of the FGFs aremediated by a family of type I transmembrane tyrosine kinases which undergodimerization and autophosphorylation after ligand binding. Four distinctgenes encoding closely related FGF receptors, FGF R1-4, are known.
Source: Murine myeloma cellline, NS0-derived
Form: Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence: Ala33
Molecular Weight: 63 kDa
Activity: Measuredby its ability to inhibit FGF acidicdependent proliferation of NR6R-3T3 mousefibroblasts. The ED50 for this effect is typically 2-6 ng/mL.
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE: 100-110kDa, reducing conditions
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 100 μg/mL in sterile PBS
Storage: Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: Fgfr3 fibroblast growth factorreceptor 3 [ Mus musculus ]
Official Symbol: Fgfr3
Synonyms: Fgfr3;fibroblast growth factor receptor 3; FR3; Mfr3; sam3; CD333; Flg-2; HBGFR;Fgfr-3; fibroblast growth factor receptor 3; heparin-binding growth factorreceptor; EC; mCG_16331
Gene ID: 14184
mRNA Refseq: NM_001163215
Protein Refseq: NP_001156687
UniProt ID: Q61851
Chromosome Location: 5 B; 5 20.0 cM
Pathway: Downstream signalingof activated FGFR; ESC Pluripotency Pathways; FGFR ligand binding andactivation; IRS-mediated signalling; IRS-related events; Insulin receptorsignalling cascade; MAPK signaling pathway; PI-3K cascade; Pathways incancer; Phospholipase C-mediated cascade; Regulation of Actin Cytoskeleton; Signalingby FGFR; Signaling by Insulin receptor; Bladder cancer; EndochondralOssification
Function: ATP binding;fibroblast growth factor binding; fibroblast growth factor-activated receptoractivity; kinase activity; nucleotide binding; protein binding; proteintyrosine kinase activity; receptor activity; transferase activity;transmembrane receptor protein tyrosine kinase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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