"Fgfr2" Related Products

Recombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged

Cat. No. : Fgfr2-542M
Product Overview : Recombinant Mouse Fgfr2protein was expressed in Sf 21 with the Fc part of human IgG1 Pro100-Lys330(C-terminus) and Arg41-Glu308 (N-terminus).
Description : Fibroblast growthfactors (FGFs) comprise a family of at least eighteen structurally relatedproteins that are involved in a multitude of physiological and pathologicalcellular processes, including cell growth, differentiation, angiogenesis,wound healing and tumorgenesis. The biological activities of the FGFs aremediated by a family of type I transmembrane tyrosine kinases which undergodimerization and autophosphorylation after ligand binding. Four distinctgenes encoding closely related FGF receptors, FGF R1-4, are known.
Source : Spodopterafrugiperda, Sf 21 (baculovirus)-derived
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Arg41
Molecular Weight : 56 kDa
Activity : Measuredby its ability to inhibit FGF acidicdependent proliferation of NR6R-3T3 mousefibroblasts. The ED50 for this effect is typically 0.5-2 ng/mL.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 74 kDa,reducing conditions
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100 μg/mL in sterile PBS
Storage : Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : Fgfr2 fibroblast growth factorreceptor 2 [ Mus musculus ]
Official Symbol : Fgfr2
Synonyms : Fgfr2; fibroblastgrowth factor receptor 2; Bek; svs; KGFR; Fgfr7; Fgfr-2; Fgfr-7; KGFRTr;AU043015; AW556123; fibroblast growth factor receptor 2; keratinocyte growthfactor receptor; EC 2.7.10.1; CD332; Ect1
Gene ID : 14183
mRNA Refseq : NM_010207
Protein Refseq : NP_034337
UniProt ID : P21803
Chromosome Location : 7 F3; 7
Pathway : Downstream signalingof activated FGFR; ESC Pluripotency Pathways; FGFR ligand binding andactivation; FGFR2 ligand binding and activation; IRS-mediated signalling; IRS-relatedevents; Insulin receptor signalling cascade; MAPK signaling pathway; PI-3Kcascade; Pathways in cancer; Phospholipase C-mediated cascade; Regulation ofActin Cytoskeleton; Endocytosis; Signaling by FGFR; Signaling by Insulinreceptor
Function : ATP binding;fibroblast growth factor 1 binding; fibroblast growth factor binding;fibroblast growth factor-activated receptor activity; heparin binding; kinaseactivity; nucleotide binding; protein binding; protein homodimerizationactivity; protein kinase activity; protein tyrosine kinase activity; receptoractivity; transferase activity; transmembrane receptor protein tyrosinekinase activity

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