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Active Recombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged

Cat.No. : Fgfr2-542M
Product Overview : Recombinant Mouse Fgfr2protein was expressed in Sf 21 with the Fc part of human IgG1 Pro100-Lys330(C-terminus) and Arg41-Glu308 (N-terminus).
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Cat. No. : Fgfr2-542M
Description : Fibroblast growthfactors (FGFs) comprise a family of at least eighteen structurally relatedproteins that are involved in a multitude of physiological and pathologicalcellular processes, including cell growth, differentiation, angiogenesis,wound healing and tumorgenesis. The biological activities of the FGFs aremediated by a family of type I transmembrane tyrosine kinases which undergodimerization and autophosphorylation after ligand binding. Four distinctgenes encoding closely related FGF receptors, FGF R1-4, are known.
Source : Spodopterafrugiperda, Sf 21 (baculovirus)-derived
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Arg41
Molecular Weight : 56 kDa
Activity : Measuredby its ability to inhibit FGF acidicdependent proliferation of NR6R-3T3 mousefibroblasts. The ED50 for this effect is typically 0.5-2 ng/mL.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 74 kDa,reducing conditions
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100 μg/mL in sterile PBS
Storage : Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : Fgfr2 fibroblast growth factorreceptor 2 [ Mus musculus ]
Official Symbol : Fgfr2
Synonyms : Fgfr2; fibroblastgrowth factor receptor 2; Bek; svs; KGFR; Fgfr7; Fgfr-2; Fgfr-7; KGFRTr;AU043015; AW556123; fibroblast growth factor receptor 2; keratinocyte growthfactor receptor; EC 2.7.10.1; CD332; Ect1
Gene ID : 14183
mRNA Refseq : NM_010207
Protein Refseq : NP_034337
UniProt ID : P21803
Chromosome Location : 7 F3; 7
Pathway : Downstream signalingof activated FGFR; ESC Pluripotency Pathways; FGFR ligand binding andactivation; FGFR2 ligand binding and activation; IRS-mediated signalling; IRS-relatedevents; Insulin receptor signalling cascade; MAPK signaling pathway; PI-3Kcascade; Pathways in cancer; Phospholipase C-mediated cascade; Regulation ofActin Cytoskeleton; Endocytosis; Signaling by FGFR; Signaling by Insulinreceptor
Function : ATP binding;fibroblast growth factor 1 binding; fibroblast growth factor binding;fibroblast growth factor-activated receptor activity; heparin binding; kinaseactivity; nucleotide binding; protein binding; protein homodimerizationactivity; protein kinase activity; protein tyrosine kinase activity; receptoractivity; transferase activity; transmembrane receptor protein tyrosinekinase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is FGFR2 linked to developmental disorders? 01/01/2022

Mutations in FGFR2 are associated with various developmental disorders, impacting the development of the skull, limbs, and other structures.

Can FGFR2 be targeted for personalized cancer therapy? 04/19/2021

Yes, targeting FGFR2 mutations allows for more personalized and precise therapeutic approaches in cancer treatment.

Are there clinical trials involving FGFR2 inhibitors? 01/24/2020

Yes, numerous clinical trials are underway to evaluate the efficacy of FGFR2 inhibitors in treating various cancers and developmental disorders.

How does FGFR2 impact wound healing? 02/28/2019

FGFR2 is involved in the regulation of cell migration and tissue repair, contributing to the process of wound healing.

Are there any side effects associated with FGFR2 inhibitors? 08/28/2018

Common side effects of FGFR2 inhibitors include fatigue, nausea, and hypertension, which are being studied for better management.

Customer Reviews (3)

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Reviews
08/24/2017

    The FGFR2 protein is an outstanding product that possesses exceptional quality, making it an ideal choice for my experimental needs.

    03/05/2017

      What sets FGFR2 apart is the manufacturer's unparalleled technical support.

      09/13/2016

        The versatility of the FGFR2 protein makes it a valuable asset in my research.

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