"FOLR3" Related Products

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Recombinant Human Folate Receptor 3 (Gamma), His-tagged

Cat. No.: FOLR3-557H
Product Overview: Recombinant Human FOLR3protein was expressed in Murine myeloma cell line with a C-terminal 6-His tag.Ala22-Ser245 & Ser26-Ser245.
Description: Folate receptor 3(FOLR3), also known as folate receptor γ, is a 32 kDa protein that bindsfolic acid and reduced folates. Dietary folates are required for many keymetabolic processes including nucleotide and methionine synthesis, theinterconversion of glycine and serine, and histidine breakdown. Mature FOLR3is a glycosylated protein that contains an imperfect carboxy terminal GPIanchor sequence. A fraction of FOLR3 is GPIlinked to the cell surface, butthe majority is released as a secreted protein. Mature human FOLR3 shares 74%and 83% amino acid (aa) sequence identity with FOLR1 and FOLR2, respectively.
Source: Murine myeloma cellline, NS0-derived
Form: Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence: Ala22 & Ser26
Molecular Weight: 26 kDa
Activity: Measuredby its binding ability in a functional ELISA. When Folic Acid-Bovine SerumAlbumin is coated at 5 μg/mL (100 μL/ well), the concentration of rhFOLR3that produces 50% of the optimal binding response is found to beapproximately 0.2-1 nM.
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE: 30-40kDa, reducing conditions
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 100 μg/mL in PBS
Storage: Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: FOLR3 folate receptor 3 (gamma)[ Homo sapiens ]
Official Symbol: FOLR3
Synonyms: FOLR3;folate receptor 3 (gamma); FR-G; FR-gamma; gamma-hFR; folate receptor gamma;Folate receptor 3; OTTHUMP00000237135
Gene ID: 2352
mRNA Refseq: NM_000804
Protein Refseq: NP_000795
MIM: 602469
UniProt ID: P41439
Chromosome Location: 11q13
Function: folic acid binding;receptor activity

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