| Cat. No. : |
FOLR3-557H |
| Description : |
Folate receptor 3(FOLR3), also known as folate receptor γ, is a 32 kDa protein that bindsfolic acid and reduced folates. Dietary folates are required for many keymetabolic processes including nucleotide and methionine synthesis, theinterconversion of glycine and serine, and histidine breakdown. Mature FOLR3is a glycosylated protein that contains an imperfect carboxy terminal GPIanchor sequence. A fraction of FOLR3 is GPIlinked to the cell surface, butthe majority is released as a secreted protein. Mature human FOLR3 shares 74%and 83% amino acid (aa) sequence identity with FOLR1 and FOLR2, respectively. |
| Source : |
Mammalian cells |
| Form : |
Lyophilized from a0.2 μm filtered solution in PBS. |
| N-terminalSequence : |
Ala22 & Ser26 |
| Molecular Weight : |
26 kDa |
| Activity : |
Measuredby its binding ability in a functional ELISA. When Folic Acid-Bovine SerumAlbumin is coated at 5 μg/mL (100 μL/ well), the concentration of rhFOLR3that produces 50% of the optimal binding response is found to beapproximately 0.2-1 nM. |
| Endotoxin Level : |
<1.0 EUper 1 μg of the protein by the LAL method. |
| SDS-PAGE : |
30-40kDa, reducing conditions |
| Purity : |
>90%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
| Reconstitution : |
Reconstituteat 100 μg/mL in PBS |
| Storage : |
Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution. |
