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Active Recombinant Mouse BMP-binding Endothelial Regulator, His-tagged

Cat.No. : Bmper-5602M
Product Overview : Recombinant Mouse Bmperprotein was expressed in Murine myeloma cell line Val34-Arg685 with anN-terminal 9-His tag. Ala39-Asp369 & Pro370-Arg685.
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Cat. No. : Bmper-5602M
Description : Bmper, also known asbone morphogenetic proteinbinding endothelial cell precursorderivedregulator, is a secreted chordinlike protein that modulates the BMP signalingpathway. Mouse Bmper is synthesized as a 685 amino acid (aa) residueprecursor protein with a putative 39 aa signal peptide, five tandemchordinlike cysteinerich (CR) domains, a partial von Willebrand factor type Ddomain (vWD), and a carboxyl trypsin inhibitorlike cysteinerich domain (TIL).Secreted Bmper is reported to be proteolytically cleaved to generate twofragments that are disulfide linked.
Source : Mammalian cells
Form : Lyophilized from a0.2 μm filtered solution in PBS with BSA as a carrier protein.
N-terminalSequence : His, Ala39 &Pro370
Molecular Weight : 36-39kDa & 50-55 kDa
Activity : Measuredby its ability to inhibit rhBMP-4-induced alkaline phosphatase production byATDC5 mouse chondrogenic cells. Binnerts, M.E. et al. (2004) Biochem.Biophys. Res. Commun. 315:272. The ED50 for this effect istypically 0.5-2 μg/mL in the presence of 75 ng/mL of rhBMP-4.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 36-39kDa, reducing conditions
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 250 μg/mL in sterile PBS that containing at least 0.1% human or bovineserum albumin.
Storage : Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt,-20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name : Bmper BMP-binding endothelialregulator [ Mus musculus ]
Official Symbol : Bmper
Synonyms : Bmper; BMP-bindingendothelial regulator; Cv2; CV-2; Crim3; 3110056H04Rik; BMP-bindingendothelial regulator protein; mCV2; crossveinless-2; crossveinless 2 homolog;protein crossveinless-2; bone morphogenetic protein-binding endothelial cellprecursor-derived regulator
Gene ID : 73230
mRNA Refseq : NM_028472
Protein Refseq : NP_082748
UniProt ID : Q8CJ69
Chromosome Location : 9; 9 A4
Function : protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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