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Active Recombinant Mouse Glycoprotein 5 (platelet), His-tagged

Cat.No. : Gp5-5621M
Product Overview : Recombinant Mouse Gp5protein was expressed in Murine myeloma cell line with a C-terminal 6-Histag. Met1-Gly522.
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Cat. No. : Gp5-5621M
Description : Gp5 is an 83 kDatype I transmembrane (TM) glycoprotein of the leucine-rich repeat (LRR)family. It is expressed exclusively within the platelet / megakaryocytelineage, where it noncovalently interacts with other platelet TM LRRproteins, GPIbα/β and GPIX, at a ratio of one GPV to two of each othersubunit. The GPI-V-IX complex tethers platelets to von Willebrand factor onthe surface of injured endothelial cells. Absence of the complex results inBernard-Soulier syndrome, a rare bleeding disorder.
Source : Mammalian cells
Form : Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence : Gln17
Molecular Weight : 57.5 kDa
Activity : Measuredby its binding ability in a functional ELISA. When Recombinant Mouse Gp5 is coated at 5 μg/mL, the concentration of RecombinantHuman vWFA2 that produces 50% optimal binding response is found to beapproximately 0.25-1.25 μg/mL
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
SDS-PAGE : 70-90kDa, reducing conditions
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 500 μg/mL in PBS
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months fromdate of receipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterileconditions after reconstitution. 3 months, -20 to -70°C under sterileconditions after reconstitution.
Gene Name : Gp5 glycoprotein 5 (platelet) [Mus musculus ]
Official Symbol : Gp5
Synonyms : Gp5;glycoprotein 5 (platelet); GPV; platelet glycoprotein V; GP V; glycoprotein V(platelet); Uncharacterized protein
Gene ID : 14729
mRNA Refseq : NM_008148
Protein Refseq : NP_032174
UniProt ID : Q9QZU3
Chromosome Location : 16 B2; 16
Pathway : ECM-receptorinteraction; Formation of Fibrin Clot (Clotting Cascade); GP1b-IX-Vactivation signalling; Hematopoietic cell lineage; Hemostasis; IntrinsicPathway; Platelet Adhesion to exposed collagen; Platelet Aggregation (PlugFormation); Platelet activation
Function : collagen binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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