Active Recombinant Mouse Dentin Matrix Protein 1, His-tagged

• Cat.No.: Dmp1-407M
• Product Overview: Recombinantmouse Dmp1 protein was expressed in Murine myeloma cell line, NS0-derived, with a C-terminal6-His tag.Leu17-Tyr503.

Specification

• Cat. No.: Dmp1-407M
• Description: Dmp1 is a member ofthe SIBLING family of proteins that includes bone sialoprotein, dentinsialophosphoprotein, MEPE, and osteopontin. These are highly phosphorylated integrinbindingproteins that are rich in acidic amino acids.
• Source: Mammalian cells
• Form: Lyophilized from a0.2 μm filtered solution in PBS.
• N-terminal Sequence: Leu17
• Molecular Weight: 52.9 kDa
• Activity: Measured by itsbinding ability in a functional ELISA. Immobilized rhIntegrin αVß3 at 5 μg/mLcan bind rmDMP-1 with an apparent KD < 25 nM.
• Endotoxin Level: <1.0 EU per 1 μgof the protein by the LAL method.
• Purity: >85%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstitute at 100μg/mL in sterile PBS.
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month,2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions afterreconstitution.

Gene Information

• Gene Name: Dmp1dentin matrix protein 1 [ Mus musculus ]
• Official Symbol: Dmp1
• Synonyms: Dmp1; dentinmatrix protein 1; PP; Dmp; AV020965; dentinmatrix acidic phospoprotein 1; AG1; DMP-1; serine rich acidic phospoprotein
• Gene ID: 13406
• mRNA Refseq: NM_016779
• Protein Refseq: NP_058059
• UniProt ID: O5518
• Chromosome Location: 5
• Function: extracellularmatrix binding

Reviews

02/01/2022

This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.

12/16/2020

The DMP1 protein offers numerous advantages in trials and research experiments.

11/01/2017

Not only does it provide reliable and consistent results due to its high quality and purity, but it also holds significant value in understanding cellular processes and disease mechanisms.

Q&As

Can DMP1 be a target for drug development?

Yes, targeting DMP1 in drug development may offer new avenues for treating conditions related to bone and dentin abnormalities.

Are there therapeutic applications of DMP1 in bone-related conditions?

Research suggests that DMP1 may have therapeutic potential in promoting bone regeneration and treating conditions like osteoporosis.

How does DMP1 contribute to the repair of bone fractures?

DMP1 is involved in the repair and remodeling of bone tissue after fractures by influencing the mineralization and structural integrity of the newly formed bone.

How can DMP1 be utilized in diagnostic procedures?

DMP1 levels can be measured in biological samples, such as blood or saliva, to assess the potential presence of dental or skeletal disorders and to monitor disease progression.

Is there a connection between DMP1 and periodontal disease?

Some studies suggest that DMP1 may play a role in maintaining the health of periodontal tissues, and alterations in its expression could be associated with periodontal disease.