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Active Recombinant Mouse Dipeptidylpeptidase 4, His-tagged

Cat.No. : Dpp4-413M
Product Overview : Recombinantmouse Dpp4 protein was expressed in Murine myeloma cell line, NS0-derived, with a C-terminal9-His tag.Ser29-His760.
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Cat. No. : Dpp4-413M
Description : Dpp4 is a serineexopeptidase that releases Xaa-Pro dipeptides from the N-terminus of oligo- andpolypeptides. It is a type II membrane protein consisting of a shortcytoplasmic tail, a transmembrane domain, and a long extracellular domain.
Source : Mammalian cells
Form : Lyophilized from a0.2 μm filtered solution in Tris and Nacl.
N-terminal Sequence : Ser29
Molecular Weight : 86 kDa
Activity : Measured by itsability to cleave the fluorogenic peptide substrate, Gly-Pro-7-amido-4-methylcoumarin(GP-AMC). The specific activity is > 2,500 pmoles/min/μg, as measuredunder the described conditions. See Activity Assay Protocol.
Endotoxin Level : <1.0 EU per 1 μgof the protein by the LAL method.
Purity : >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3months, -20 to -70 °C under sterile conditions after reconstitution.
Gene Name : Dpp4dipeptidylpeptidase 4 [ Mus musculus ]
Official Symbol : Dpp4
Synonyms : Dpp4; dipeptidylpeptidase4; Cd26;THAM; Dpp-4; OTTMUSP00000013700;dipeptidyl peptidase 4; DPP IV; dipeptidyl peptidase IV; thymocyte-activatingmolecule; T-cell activation antigen CD26; EC 3.4.14.5; CD26
Gene ID : 13482
mRNA Refseq : NM_010074
Protein Refseq : NP_034202
UniProt ID : P28843
Chromosome Location : 2
Pathway : Incretin Synthesis, Secretion, andInactivation; Integration of energy metabolism; Metabolism; Protein digestionand Incretin Synthesis, Secretion, and Inactivation; Integration of energymetabolism; Metabolism; Protein digestion and absorption; Regulation ofInsulin Secretion; Synthesis, Secretion, and Inactivation of Glucagon-likePeptide-1 (GLP-1)
Function : aminopeptidase activity; collagen binding;dipeptidyl-peptidase activity; hydrolase activity; peptidase activity;peptide binding; protease binding; protein homodimerization activity;receptor activity; receptor binding; serine-type endopeptidase activity;serine-type peptidase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How does DPP4 relate to diabetes? 04/17/2023

DPP4 plays a crucial role in glucose homeostasis by cleaving incretin hormones. In diabetes, inhibiting DPP4 can enhance the action of these hormones, promoting insulin release and lowering blood sugar levels.

Are there any side effects associated with DPP4 inhibitors? 01/11/2022

Common side effects of DPP4 inhibitors include respiratory and urinary tract infections, headache, and nasopharyngitis. However, they are generally well-tolerated.

What clinical applications does DPP4 have in managing type 2 diabetes? 06/12/2020

Inhibitors of DPP4 are used in the treatment of type 2 diabetes to improve glycemic control. They work by prolonging the activity of incretin hormones, such as GLP-1, which stimulate insulin secretion.

Can DPP4 inhibitors be used as a monotherapy for diabetes? 03/10/2020

DPP4 inhibitors are often used as monotherapy or in combination with other antidiabetic medications to achieve optimal glycemic control.

How do DPP4 inhibitors differ from other diabetes medications? 06/11/2016

DPP4 inhibitors work by enhancing the effects of incretin hormones, while other diabetes medications may act on insulin sensitivity, insulin release, or glucose absorption.

Customer Reviews (3)

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Reviews
09/13/2019

    Its purity and efficacy make it an ideal choice for precise and accurate analysis, allowing me to generate reliable results.

    01/27/2019

      By incorporating the DPP4 Protein into their studies, scientists can confidently conduct their research, ushering in groundbreaking discoveries and novel insights within their respective domains.

      12/14/2016

        Its exceptional purity and functionality make it an ideal choice for accurate and precise analysis, ensuring reliable and reproducible results.

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