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Recombinant Mouse V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Fc-tagged

Cat. No. : Erbb3-470M
Product Overview : Recombinant Mouse Erbb3protein was expressed in Murine myeloma cell line with the Fc part of mouse IgG2a.Ser20-His641.
Description : Erbb3, also called HER3(human epidermal growth factor receptor 3) in humans, is a type I transmembraneglycoprotein that is a member of the ErbB family of tyrosine kinase receptorsnamed for a viral oncogene. ErbB family members serve as receptors for the EGFfamily of growth factors. Mouse Erbb3 contains a 19 amino acid (aa) signal sequence,a 622 aa extracellular domain (ECD), a 24 aa transmembrane region, and a 677 aacytoplasmic domain.
Source : Murine myeloma cell line,NS0-derived
Form : Lyophilized from a 0.2μm filtered solution in PBS.
N-terminalSequence : Ser20
Molecular Weight : 95.6 kDa
Activity : Measuredby its ability to bind rhNRG1ß1 extracellular domain in a functional ELISA withan estimated KD < 15 nM.
Endotoxin Level : <1.0 EUper 1 μg of the protein by the LAL method.
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : Reconstituteat 100 μg/mL in sterile PBS
Storage : Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months,-20 to -70°C under sterile conditions after reconstitution.
PDB renderingbased on 1m6b. :

Gene Name : Erbb3 v-erb-b2 erythroblastic leukemiaviral oncogene homolog 3 (avian) [ Mus musculus ]
Official Symbol : Erbb3
Synonyms : Erbb3; v-erb-b2erythroblastic leukemia viral oncogene homolog 3 (avian); Her3; C76256; Erbb-3;Erbb3r; receptor tyrosine-protein kinase erbB-3; c-erbB-3; receptor tyrosine kinase;glial growth factor receptor; proto-oncogene-like protein c-ErbB-3; avian erythroblastosisoncogene B 3 receptor; EC 2.7.10.1
Gene ID : 13867
mRNA Refseq : NM_010153
Protein Refseq : NP_034283
UniProt ID : Q61526
Chromosome Location : 10 D3; 10 70.0 cM
Pathway : Calcium signaling pathway;Endocytosis; ErbB signaling pathway; IL-6 signaling Pathway
Function : ATP binding; growth factorbinding; kinase activity; nucleotide binding; protein binding; protein heterodimerizationactivity; protein kinase activity; protein tyrosine kinase activator activity;NOT protein tyrosine kinase activity; receptor activity; receptor signaling proteintyrosine kinase activity; transferase activity; transferase activity; transmembranereceptor protein tyrosine kinase activity

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