"Erbb3" Related Products

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Recombinant Mouse V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Fc-tagged

Cat. No.: Erbb3-470M
Product Overview: Recombinant Mouse Erbb3protein was expressed in Murine myeloma cell line with the Fc part of mouse IgG2a.Ser20-His641.
Description: Erbb3, also called HER3(human epidermal growth factor receptor 3) in humans, is a type I transmembraneglycoprotein that is a member of the ErbB family of tyrosine kinase receptorsnamed for a viral oncogene. ErbB family members serve as receptors for the EGFfamily of growth factors. Mouse Erbb3 contains a 19 amino acid (aa) signal sequence,a 622 aa extracellular domain (ECD), a 24 aa transmembrane region, and a 677 aacytoplasmic domain.
Source: Murine myeloma cell line,NS0-derived
Form: Lyophilized from a 0.2μm filtered solution in PBS.
N-terminalSequence: Ser20
Molecular Weight: 95.6 kDa
Activity: Measuredby its ability to bind rhNRG1ß1 extracellular domain in a functional ELISA withan estimated KD < 15 nM.
Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution: Reconstituteat 100 μg/mL in sterile PBS
Storage: Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months,-20 to -70°C under sterile conditions after reconstitution.
Gene Name: Erbb3 v-erb-b2 erythroblastic leukemiaviral oncogene homolog 3 (avian) [ Mus musculus ]
Official Symbol: Erbb3
Synonyms: Erbb3; v-erb-b2erythroblastic leukemia viral oncogene homolog 3 (avian); Her3; C76256; Erbb-3;Erbb3r; receptor tyrosine-protein kinase erbB-3; c-erbB-3; receptor tyrosine kinase;glial growth factor receptor; proto-oncogene-like protein c-ErbB-3; avian erythroblastosisoncogene B 3 receptor; EC 2.7.10.1
Gene ID: 13867
mRNA Refseq: NM_010153
Protein Refseq: NP_034283
UniProt ID: Q61526
Chromosome Location: 10 D3; 10 70.0 cM
Pathway: Calcium signaling pathway;Endocytosis; ErbB signaling pathway; IL-6 signaling Pathway
Function: ATP binding; growth factorbinding; kinase activity; nucleotide binding; protein binding; protein heterodimerizationactivity; protein kinase activity; protein tyrosine kinase activator activity;NOT protein tyrosine kinase activity; receptor activity; receptor signaling proteintyrosine kinase activity; transferase activity; transferase activity; transmembranereceptor protein tyrosine kinase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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