"Il2ra" Related Products


Recombinant Rat Interleukin 2 Receptor, Alpha

Cat. No.: Il2ra-474R
Product Overview: Recombinant Ratll2ra protein was expressed in Chinese Hamster Ovary cell line, CHO-derived. Glu22- Gln235.
Description: Il2ra, also known asCD25, is a 55 kDa type I membrane glycoprotein that belongs to the family ofcytokine receptors that utilize the common gamma chain subunit (γc). Il2ra isprimarily expressed on activated T cells and on regulatory T cells (Treg). Therat Il2ra cDNA encodes a 267 amino acid (aa) precursor that includes a 21 aasignal peptide, a 214 aa extracellular domain (ECD) with two Sushi domains, a21 aa transmembrane segment, and an 11 aa cytoplasmic domain. Within the ECD,rat Il2ra shares 58% and 81% aa sequence identity with human and mouse IL2 Rα,respectively. It shares approximately 15% aa sequence identity with IL4, 7, 9,15, and 21 receptor subunits that also complex with γc.
Source: Chinese HamsterOvary cell line, CHO-derived.
Form: Lyophilized from a0.2 μm filtered solution in PBS.
N-terminalSequence: Glu22
MolecularWeight: 51.6 kDa (monomer)
Activity: Measured by itsability to inhibit the IL2dependent proliferation of MO7e human megakaryocyticleukemic cells. Avanzi, G. et al. (1988) Br. J. Haematol. 69:359. The ED50for this effect is typically 0.35 1.4 μg/mL in the presence of 30 ng/mL of rhIL2.
Endotoxin Level: <1.0 EU per 1 μgof the protein by the LAL method.
Purity: >95%, by SDSPAGE underreducing conditions and visualized by silver stain.
Reconstitution: Reconstitute at 500μg/mL in sterile PBS.
Storage: Use amanual defrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8 °C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.
Gene Name: Il2ra interleukin 2 receptor,alpha [ Rattus norvegicus ]
Official Symbol: Il2ra
Synonyms: Il2ra; interleukin 2receptor, alpha; IL2RAC; interleukin-2 receptor subunit alpha; IL2-RA; IL-2-RA;IL-2R subunit alpha; IL-2 receptor alpha subunit; IL-2 receptor subunit alpha;interleukin-2 receptor alpha chain; interleukin 2 receptor, alpha chain
Gene ID: 25704
mRNA Refseq: NM_013163
Protein Refseq: NP_037295
Chromosome Location: 17q12.3
Pathway: Cytokine Signalingin Immune system; Cytokine-cytokine receptor interaction; Endocytosis; HTLV-Iinfection; Hematopoietic cell lineage; IL-2 Signaling Pathway; Immune System;Inflammatory Response Pathway; Interleukin receptor SHC signaling;Interleukin-2 signaling; Interleukin-3, 5 and GM-CSF signaling; Jak-STATsignaling pathway; Measles; Signaling by Interleukins
Function: drug binding;interleukin-2 binding; interleukin-2 receptor activity; receptor activity

Online Inquiry

Note: There will be extra charge for optional service!
Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Price does not include shipping and packaging costs.Request quote for final price.

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.