| Official Full Name | interleukin 2 receptor, alpha |
| Background | Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. |
| Synonyms | Interleukin 2 receptor alpha chain; CD 25; CD25; CD25 antigen; IDDM10; IL 2 RA; IL 2 receptor alpha subunit; IL 2R; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2 RA; IL2R; IL2RA_HUMAN; IL2RAC; Interleukin 2 Receptor Alpha; Interleukin 2 receptor; Interleukin-2 receptor subunit alpha; Ly43; p55; T Cell Growth Factor Receptor; TAC; TAC Antigen; TCGFR; interleukin 2 receptor, alpha |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
il2ra involved in several pathways and played different roles in them. We selected most pathways il2ra participated on our site, such as Cytokine-cytokine receptor interaction, Endocytosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with il2ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TGFBR1; IL23; CCR6A; TNFRSF21; TNFB; CCL1; PDGFC; CSF1R; TNFRSF10C; CCL20 |
| Endocytosis | AMPH; FOLR3; KIF5C; HLA-F; ACAP3; HLA-C; PML; SPG20A; TGFBR1B; ERBB3A |
| PIK-Akt signaling pathway | CREB5; ITGA8; PPP2R5C; Pdgfa&Pdgfb; IL3; CRTC2; MTOR; OSM; RXRA; Kitl |
| Jak-STAT signaling pathway | IFNGR1; PIK3CG; IL12B; IL5RA; GM-CSF; IFNA6; LEPB; IL28A; IL23R; LEPA |
| Hematopoietic cell lineage | IL1B; CD1D2; IL9R; Il6ra; IL7R; KIT; CD36; CD59; FLT3LG; CSF3 |
| Measles | CCND1; IFNB1; MX1; Il2; GSK3B; OAS3; HSPA6; CLEC4M; CCNE1; CD3E; CD3D |
| HTLV-I infection | CD3G; POLD1; NFYB; WNT9B; HLA-DRB1; APC2; TLN1; MYBL1; PTTG2; VDAC3 |
il2ra has several biochemical functions, for example, drug binding, interleukin-2 binding, interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by il2ra itself. We selected most functions il2ra had, and list some proteins which have the same functions with il2ra. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| drug binding | DRD1A; GSTP2; TLR7; Alb; GRIK1; CHRM2; SRP54B; PIGC; CHRNB2; CHRNA7 |
| interleukin-2 binding | IL2RA; IL2RG; IL2RB |
| interleukin-2 receptor activity | IL2RB; IL2RA |
il2ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with il2ra here. Most of them are supplied by our site. Hope this information will be useful for your research of il2ra.
PASK
