Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
IL2RA involved in several pathways and played different roles in them. We selected most pathways IL2RA participated on our site, such as Cytokine-cytokine receptor interaction, Endocytosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
IL2RA has several biochemical functions, for example, drug binding, interleukin-2 binding, interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2RA itself. We selected most functions IL2RA had, and list some proteins which have the same functions with IL2RA. You can find most of the proteins on our site.
Function
Related Protein
drug binding
PPARA;MT2A;SRP54B;GPR30;CHRM1;DRD2;Alb;TYMS;CHRM3
interleukin-2 binding
IL2RB;IL2RA;IL2RG
interleukin-2 receptor activity
IL2RA;IL2RB
IL2RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2RA.
PASK
Oliveira, PRS; Dessein, H; et al. IL2RA Genetic Variants Reduce IL-2-Dependent Responses and Aggravate Human Cutaneous Leishmaniasis. JOURNAL OF IMMUNOLOGY 194:2664-2672(2015).
Savilova, AM; Chulkina, MM; et al. Expression of Immunomodulator Gene mRNA in Co-Culture of Mesenchymal Stromal Cells from the Placenta and Human Mononuclear Blood Cells. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 158:561-565(2015).
Is there any adverse effect of IL2RA combined with other drugs?
12/10/2022
The combination of IL2RA and other drugs may produce nausea, vomiting, rash and other adverse reactions, should be monitored.
How often is IL2RA used?
01/11/2022
The frequency of use of IL2RA depends on the specific situation of the patient, and is generally used 1-3 times per week.
Whether there is an effect of IL2RA?
12/17/2021
IL2RA, in the right dosage and frequency of use, can significantly relieve symptoms of diseases such as autoimmune diseases and organ transplant rejection.
Can IL2RA treat cancer?
05/18/2021
Can assist in the treatment of some types of malignant tumors, but it is not a complete cure for cancer.
How effective is IL2RA treatment?
04/07/2020
The effective rate of IL2RA therapy depends on many factors such as the type of disease, the patient's condition and the treatment regimen, and the effective rate is generally between 50% and 90%.
What are the indications for IL2RA?
01/09/2020
Indications of IL2RA include a variety of autoimmune diseases, organ transplant rejection and malignant tumors.
Structural stability of IL2RA, that is, whether it can maintain its structural integrity and functional activity under different conditions such as temperature, pH value and storage time, HPLC, CD spectroscopy and other techniques can be used to evaluate the stability. -
06/05/2021
Solubility and stability of IL2RA in physiological buffers to ensure its reliability in practical applications. -
03/14/2019
To evaluate whether IL2RA has biological activity, we can verify its IL-2 binding ability and signal transduction ability through cell experiments, which are the key functions of IL2RA. -
