IL2RA

  • Official Full Name

    interleukin 2 receptor, alpha

  • Overview

    Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
  • Synonyms

    Interleukin 2 receptor alpha chain; CD 25; CD25; CD25 antigen; IDDM10; IL 2 RA; IL 2 receptor alpha subunit; IL 2R; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2 RA; IL2R; IL2RA_HUMAN; IL2RAC; Interleukin 2 Receptor Alpha; Interleukin 2 receptor; Interleukin-2 receptor subunit alpha; Ly43; p55; T Cell Growth Factor Receptor; TAC; TAC Antigen; TCGFR; interleukin 2 receptor, alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Canine
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cattle
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Felis catus (Cat) (Felis silvestris catus)
  • Homo sapiens (Human)
  • Human
  • Monkey
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Pig
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus
  • Rhesus Macaque
  • Sus scrofa (Pig)
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • Hi-5 Insect Cell
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Avi
  • His
  • Fc
  • hFc
  • DYKDDDDK
  • GST
  • hIgG
  • Tag
  • His (Fc)
  • His(C
  • ter)
  • His\Avi
  • His|S
  • His|T7
  • human|IgG1|Fc
  • LEVLFQ
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL2RA-4951H Active Recombinant Human IL2RA Insect Cell N/A
Human IL2RA-948H Active Recombinant Human IL2RA Protein Hi-5 Insect Cell N/A
Human IL2RA-051H Active Recombinant Human IL2RA protein, Fc/Avi-tagged, Biotinylated HEK293 cells Fc/Avi Glu22-Cys213
Human IL2RA-170H Recombinant Human IL2RA protein, Fc-tagged HEK293 human/IgG1/Fc Glu22-Cys213
Human IL2RA-637H Active Recombinant Human IL2RA, His tagged HEK293 His Met1-Cys213
Human IL2RA-636H Recombinant Human IL2RA protein(Met1-Cys213), hFc-tagged HEK293 C-hFc Met1-Cys213
Human IL2RA-1325H Recombinant Human Interleukin 2 Receptor, Alpha, GST-tagged E.coli GST
Human IL2RA-99H Recombinant Human IL2RA protein, His-tagged E.coli His
Human IL2RA-1237H Recombinant Human Interleukin 2 Receptor, Alpha Insect Cell N/A
Human IL2RA-2907HCL Recombinant Human IL2RA cell lysate Human Cell N/A
Human IL2RA-5199H Recombinant Human IL2RA Protein Wheat Germ N/A
Human IL2RA-2025H Recombinant Human IL2RA protein, His-tagged HEK293 His Glu22-Cys213
Human IL2RA-170HA Recombinant Human IL2RA protein, Fc-tagged, APC labeled HEK293 Fc
Human IL2RA-170HP Recombinant Human IL2RA protein, Fc-tagged, R-PE labeled HEK293 Fc
Human IL2RA-5198H Recombinant Human IL2RA Protein HEK293 N/A
Human IL2RA-636HP Recombinant Human IL2RA protein, Fc-tagged, R-PE labeled HEK293 Fc
Human IL2RA-636HA Recombinant Human IL2RA protein, Fc-tagged, APC labeled HEK293 Fc
Human IL2RA-170HAF555 Recombinant Human IL2RA Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc Glu22-Cys213
Human IL2RA-5197H Recombinant Human IL2RA Protein E.coli N/A
Human IL2RA-025H Recombinant Human IL2RA protein, His-Avi-tagged HEK293 His-Avi It contains Glu22-Cys213 .
Human IL2RA-151H Recombinant Human IL2RA Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human IL2RA-636HAF555 Recombinant Human IL2RA Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Human IL2RA-636HAF488 Recombinant Human IL2RA Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Human IL2RA-170HAF488 Recombinant Human IL2RA Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc Glu22-Cys213
Human IL2RA-5756HF Recombinant Full Length Human IL2RA Protein In Vitro Cell Free System 476 amino acids
Human IL2RA-637HAF555 Recombinant Human IL2RA Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 203
Human IL2RA-637HAF488 Recombinant Human IL2RA Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 203
Human IL2RA-170HF Recombinant Human IL2RA Protein, hFc-tagged, FITC conjugated HEK293 hFc Glu22-Cys213
Human IL2RA-320H Recombinant Human IL2RA Protein, Fc-tagged HEK293 Fc 272
Human IL2RA-170HAF647 Recombinant Human IL2RA Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc Glu22-Cys213
Human IL2RA-1632H Active Recombinant Human IL2RA protein, Fc-Avi-tagged, Biotinylated, MALS verified HEK293 C-Fc-Avi Glu 22 - Cys 213
Human IL2RA-01H Recombinant Human IL2RA protein, hIgG-His-tagged Insect Cell hIgG-His-Tag 22-240aa
Human CDA085P Recombinant Human CD-25 E.coli N/A
Human IL2RA-636HAF647 Recombinant Human IL2RA Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Human IL2RA-1715H Recombinant Human IL2RA protein(22-185aa), His-GST-tagged E.coli N-His-GST 22-185aa
Human IL2RA-319H Recombinant Human IL2RA Protein, His-tagged HEK293 His 272
Human IL2RA-1633H Active Recombinant Human IL2RA protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Glu22-Cys213
Human IL2RA-637HAF647 Recombinant Human IL2RA Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 203
Human IL2RA-2407H Recombinant Human IL2RA Protein (Glu22-Gln240), His tagged E.coli His Glu22-Gln240
Human IL2RA-1634H Active Recombinant Human IL2RA protein, Fc-tagged HEK293 Fc Glu22-Cys213
Human IL2RA-4270H Recombinant Human IL2RA Protein (Met1-Gln240), C-His tagged Mammalian cells C-His Met1-Gln240
Human IL2RA-636HF Recombinant Human IL2RA Protein, Fc-tagged, FITC conjugated HEK293 Fc
Human IL2RA-637HF Recombinant Human IL2RA Protein, His-tagged, FITC conjugated HEK293 His 203
Human IL2RA-43H Recombinant Human IL2RA Protein, C-Avi&His tagged, Biotinylated HEK293 C-Avi&His Glu22-Gln240
Human IL2RA-186H Recombinant Human IL2RA Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter) Glu22-Cys213
Human IL2RA-216H Recombinant Human IL2RA Protein, His\Avi-tagged HEK293 His\Avi
Human IL2RA-179I Active Recombinant Human IL2RA Protein (205 aa), His-tagged HEK293 His 205
Mouse Il2ra-5654M Active Recombinant Mouse Interleukin 2 Receptor, Alpha Chain, His-tagged Mammalian cells His
Mouse IL2RA-1246M Acitve Recombinant Mouse IL2RA protein(Met1-Lys236), His-tagged HEK293 C-His Met1-Lys236
Mouse Il2ra-4021M Recombinant Mouse Il2ra protein, His-tagged HEK293 His Glu22-Lys236
Mouse Il2ra-1865M Recombinant Mouse Il2ra protein, His & S-tagged E.coli His/S Glu22~Tyr235 (Accession # P01590)
Mouse IL2RA-2024MCL Recombinant Mouse IL2RA cell lysate Human Cell N/A
Mouse Il2ra-5424M Recombinant Mouse Il2ra Protein (Met1-Lys236), His tagged Mammalian cells His Met1-Lys236
Mouse Il2ra-4021MF Recombinant Mouse Il2ra Protein, His-tagged, FITC conjugated HEK293 His Glu22-Lys236
Mouse Il2ra-4021MAF488 Recombinant Mouse Il2ra Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Glu22-Lys236
Mouse Il2ra-1677M Recombinant Mouse Il2ra Protein, His-tagged E.coli N-His Glu22-Lys236
Mouse Il2ra-1676M Recombinant Mouse Il2ra Protein, His-tagged E.coli N-His Glu22-Lys236
Mouse Il2ra-4021MAF647 Recombinant Mouse Il2ra Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Glu22-Lys236
Mouse Il2ra-4513M-B Recombinant Mouse Il2ra Protein Pre-coupled Magnetic Beads HEK293
Mouse Il2ra-5704M Active Recombinant Mouse Il2ra protein(Met1-Lys236), hFc-tagged HEK293 C-hFc Met1-Lys236
Mouse Il2ra-4513M Recombinant Mouse Il2ra Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il2ra-4021MAF555 Recombinant Mouse Il2ra Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Glu22-Lys236
Rat Il2ra-474R Active Recombinant Rat Interleukin 2 Receptor, Alpha CHO N/A
Rat Il2ra-1867R Recombinant Rat Il2ra protein, His-tagged E.coli His Cys24~Met225 (Accession # P26897)
Rat IL2RA-3043R Recombinant Rat IL2RA Protein Mammalian Cell His
Rat Il2ra-1868R Recombinant Rat Il2ra protein, His & S-tagged E.coli His/S Leu23~Gln235 (Accession # P26897)
Rat IL2RA-2698R Recombinant Rat IL2RA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IL2RA-2698R-B Recombinant Rat IL2RA Protein Pre-coupled Magnetic Beads HEK293
Rat IL2RA-942R Recombinant Rat IL2RA Protein (Met1-Gln235), His-tagged Insect Cell His Met1-Gln235
Monkey IL2RA-134CAF555 Recombinant Cynomolgus IL2RA Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 203
Monkey IL2RA-133CAF555 Recombinant Monkey IL2RA Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 433
Monkey IL2RA-133CAF647 Recombinant Monkey IL2RA Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 433
Monkey IL2RA-133CAF488 Recombinant Monkey IL2RA Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 433
Monkey IL2RA-135CAF647 Recombinant Cynomolgus IL2RA Protein, LEVLFQ-tagged, Alexa Fluor 647 conjugated HEK293 LEVLFQ 199
Monkey IL2RA-135CAF555 Recombinant Cynomolgus IL2RA Protein, LEVLFQ-tagged, Alexa Fluor 555 conjugated HEK293 LEVLFQ 199
Monkey IL2RA-133CF Recombinant Monkey IL2RA Protein, Fc-tagged, FITC conjugated HEK293 Fc 433
Monkey IL2RA-134CAF647 Recombinant Cynomolgus IL2RA Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 203
Monkey IL2RA-135CF Recombinant Cynomolgus IL2RA Protein, LEVLFQ-tagged, FITC conjugated HEK293 LEVLFQ 199
Monkey IL2RA-134CF Recombinant Cynomolgus IL2RA Protein, His-tagged, FITC conjugated HEK293 His 203
Monkey IL2RA-135CAF488 Recombinant Cynomolgus IL2RA Protein, LEVLFQ-tagged, Alexa Fluor 488 conjugated HEK293 LEVLFQ 199
Monkey IL2RA-134CAF488 Recombinant Cynomolgus IL2RA Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 203
Bos taurus (Bovine) RFL7065BF Recombinant Full Length Bovine Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-275)
Canine IL2RA-460C Active Recombinant Canine IL2RA, His-tagged Mammalian cells His
Canine IL2RA-2182C Active Recombinant Canine IL2RA protein, His-tagged HEK293 His Asp 22 - Gln 237
Canine IL2RA-4C Recombinant Canine IL2RA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canine IL2RA-4C-B Recombinant Canine IL2RA Protein Pre-coupled Magnetic Beads HEK293
Canis lupus familiaris (Dog) (Canis familiaris) RFL33866CF Recombinant Full Length Dog Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-268)
Cattle IL2RA-1864C Recombinant Cattle IL2RA protein, His & T7-tagged E.coli His/T7 Glu22~Gln243 (Accession # P12342)
Cynomolgus IL2RA-618C Active Recombinant Cynomolgus IL2RA protein HEK293 N/A Met1-Arg213
Cynomolgus IL2RA-133C Active Recombinant Cynomolgus IL2RA, Fc tagged HEK293 Fc Met1-Arg213
Cynomolgus IL2RA-1631C Active Recombinant Cynomolgus IL2RA protein, His-tagged HEK293 His Glu22-Glu238
Cynomolgus IL2RA-134C Recombinant Cynomolgus IL2RA, His tagged HEK293 His Met1-Arg213
Cynomolgus Monkey IL2RA-135C Recombinant Cynomolgus IL2RA, LEVLFQ tagged Human Cell Fc
Cynomolgus Monkey IL2RA-1015CCL Recombinant Cynomolgus IL2RA cell lysate Human Cell N/A
Cynomolgus Monkey IL2RA-365C-B Recombinant Cynomolgus Monkey IL2RA Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey IL2RA-365C Recombinant Cynomolgus Monkey IL2RA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Felis catus (Cat) (Felis silvestris catus) RFL26789FF Recombinant Full Length Cat Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-275)
Homo sapiens (Human) RFL19373HF Recombinant Full Length Human Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-272)
Mus musculus (Mouse) RFL25627MF Recombinant Full Length Mouse Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-268)
Ovis aries (Sheep) RFL15135OF Recombinant Full Length Sheep Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-275)
Rattus norvegicus (Rat) RFL15962RF Recombinant Full Length Rat Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-267)
Rhesus IL2RA-247R Recombinant Rhesus IL2RA protein, His & Avi-tagged, Biotinylated HEK293 His & Avi Met1-Arg213
Rhesus Macaque IL2RA-2247R Recombinant Rhesus monkey IL2RA Protein, His-tagged Mammalian Cell His
Rhesus Macaque IL2RA-2068R Recombinant Rhesus Macaque IL2RA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque IL2RA-2068R-B Recombinant Rhesus Macaque IL2RA Protein Pre-coupled Magnetic Beads HEK293
Sus scrofa (Pig) RFL934SF Recombinant Full Length Pig Interleukin-2 Receptor Subunit Alpha(Il2Ra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (22-270)
Pig IL2RA-1866P Recombinant Pig IL2RA protein, His & T7-tagged E.coli His/T7 Gly22~Gln245 (Accession # O02733)
Chicken IL2RA-6165C Recombinant Chicken IL2RA Mammalian Cell His
CBCRY33 Interleukin-2 with its alpha Receptor E.coli N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • IL2RA Related Signal Pathway

IL2RA involved in several pathways and played different roles in them. We selected most pathways IL2RA participated on our site, such as Cytokine-cytokine receptor interaction, Endocytosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL2RA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionXCL1;INHBA;VEGFB;EDAR;TGFBR1B;TNFB;CXCL16;IL13RA1;FLT3
EndocytosisPLD1A;VPS24;CYTH4B;SPG20;ADRB1;HSPA1L;ARFGEF1;ARAP2;GIT1
PIK-Akt signaling pathwayLPAR2;CCND1;DDIT4;TCL1B4;ANGPT1;SGK1;PHLPP1;YWHAZ;RHEB
Jak-STAT signaling pathwayIL21R.1;JAK2B;PTPN6;AOX2P;IL12RB1;EPOR;IL28A;CRFB4;IL15
Hematopoietic cell lineageGP1BB;CR2;IL7;IL5;CD3G;ITGA6;MME;IL1R2;CD3D
MeaslesDDX58;CLEC4M;TP73;TNFRSF10B;CD209;CCND1;STAT2;AKT1;HSPA1A
HTLV-I infectionITGAL;MYBL1;TGFB2;HLA-F;ATF3;PRKACA;FZD3;HLA-DQA1;GPS2

IL2RA has several biochemical functions, for example, drug binding, interleukin-2 binding, interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL2RA itself. We selected most functions IL2RA had, and list some proteins which have the same functions with IL2RA. You can find most of the proteins on our site.

Function Related Protein
drug bindingPDE4C;P2RX4;SRP54;PDE2A;SFRP1;SLC6A4A;DHODH;Alb;ADH1
interleukin-2 bindingIL2RG;IL2RA;IL2RB
interleukin-2 receptor activityIL2RA;IL2RB

IL2RA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL2RA here. Most of them are supplied by our site. Hope this information will be useful for your research of IL2RA.

PASK

Gene Family

IL

Research Area

Related articles

Oliveira, PRS; Dessein, H; et al. IL2RA Genetic Variants Reduce IL-2-Dependent Responses and Aggravate Human Cutaneous Leishmaniasis. JOURNAL OF IMMUNOLOGY 194:2664-2672(2015).
Savilova, AM; Chulkina, MM; et al. Expression of Immunomodulator Gene mRNA in Co-Culture of Mesenchymal Stromal Cells from the Placenta and Human Mononuclear Blood Cells. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 158:561-565(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there any adverse effect of IL2RA combined with other drugs? 12/10/2022

The combination of IL2RA and other drugs may produce nausea, vomiting, rash and other adverse reactions, should be monitored.

How often is IL2RA used? 01/11/2022

The frequency of use of IL2RA depends on the specific situation of the patient, and is generally used 1-3 times per week.

Whether there is an effect of IL2RA? 12/17/2021

IL2RA, in the right dosage and frequency of use, can significantly relieve symptoms of diseases such as autoimmune diseases and organ transplant rejection.

Can IL2RA treat cancer? 05/18/2021

Can assist in the treatment of some types of malignant tumors, but it is not a complete cure for cancer.

How effective is IL2RA treatment? 04/07/2020

The effective rate of IL2RA therapy depends on many factors such as the type of disease, the patient's condition and the treatment regimen, and the effective rate is generally between 50% and 90%.

What are the indications for IL2RA? 01/09/2020

Indications of IL2RA include a variety of autoimmune diseases, organ transplant rejection and malignant tumors.

Customer Reviews (3)

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Reviews
09/29/2022

    Security is very high and can be used with confidence.

    06/05/2021

      Structure is very stable and not prone to mutation.

      03/14/2019

        The amount of expression is very high and can be easily detected.

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