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Official Full Name interleukin 2 receptor, alpha
Background Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Synonyms Interleukin 2 receptor alpha chain; CD 25; CD25; CD25 antigen; IDDM10; IL 2 RA; IL 2 receptor alpha subunit; IL 2R; IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2 RA; IL2R; IL2RA_HUMAN; IL2RAC; Interleukin 2 Receptor Alpha; Interleukin 2 receptor; Interleukin-2 receptor subunit alpha; Ly43; p55; T Cell Growth Factor Receptor; TAC; TAC Antigen; TCGFR; interleukin 2 receptor, alpha
    • Species :
    • Canine
    • Cattle
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Hi-5 Insect Cell
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • S
    • T7
    • His-Avi
    • human
    • IgG1
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL2RA-025H Recombinant Human IL2RA protein, His-Avi-tagged HEK293 His-Avi
    Human IL2RA-170HA Recombinant Human IL2RA protein, Fc-tagged, APC labeled HEK293 Fc
    Human IL2RA-170HP Recombinant Human IL2RA protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human IL2RA-2025H Recombinant Human IL2RA protein, His-tagged HEK293 His
    Human IL2RA-636HA Recombinant Human IL2RA protein, Fc-tagged, APC labeled HEK293 Fc
    Human IL2RA-636HP Recombinant Human IL2RA protein, Fc-tagged, R-PE labeled HEK293 Fc
    Rat IL2RA-942R Recombinant Rat IL2RA Protein (Met1-Gln235), His-tagged Insect Cell His
    Human CDA085P Recombinant Human CD-25 E.coli N/A
    Human IL2RA-1237H Recombinant Human Interleukin 2 Receptor, Alpha Insect Cell N/A
    Human IL2RA-1325H Recombinant Human Interleukin 2 Receptor, Alpha, GST-tagged E.coli GST
    Human IL2RA-170H Recombinant Human IL2RA protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL2RA-2907HCL Recombinant Human IL2RA cell lysate Human Cell N/A
    Human IL2RA-4951H Recombinant Human IL2RA Insect Cell N/A
    Human IL2RA-5197H Recombinant Human IL2RA Protein E.coli N/A
    Human IL2RA-5198H Recombinant Human IL2RA Protein HEK293 N/A
    Human IL2RA-5199H Recombinant Human IL2RA Protein Wheat Germ N/A
    Human IL2RA-636H Recombinant Human IL2RA, Fc tagged Human Cell Fc
    Human IL2RA-637H Recombinant Human IL2RA, His tagged Human Cell His
    Human IL2RA-948H Recombinant Human IL2RA Protein Hi-5 Insect Cell N/A
    Human IL2RA-99H Recombinant Human IL2RA protein, His-tagged E.coli His
    Mouse Il2ra-1865M Recombinant Mouse Il2ra protein, His & S-tagged E.coli His/S
    Mouse IL2RA-2024MCL Recombinant Mouse IL2RA cell lysate Human Cell N/A
    Mouse Il2ra-4021M Recombinant Mouse Il2ra protein, His-tagged HEK293 His
    Mouse Il2ra-5654M Recombinant Mouse Interleukin 2 Receptor, Alpha Chain, His-tagged NS0 His
    Rat Il2ra-1867R Recombinant Rat Il2ra protein, His-tagged E.coli His
    Rat Il2ra-1868R Recombinant Rat Il2ra protein, His & S-tagged E.coli His/S
    Rat IL2RA-3043R Recombinant Rat IL2RA Protein Mammalian Cell His
    Rat Il2ra-474R Recombinant Rat Interleukin 2 Receptor, Alpha CHO N/A
    Cynomolgus Monkey IL2RA-1015CCL Recombinant Cynomolgus IL2RA cell lysate Human Cell N/A
    Cynomolgus Monkey IL2RA-133C Recombinant Cynomolgus IL2RA, Fc tagged Human Cell His
    Cynomolgus Monkey IL2RA-134C Recombinant Cynomolgus IL2RA, His tagged Human Cell His
    Cynomolgus Monkey IL2RA-135C Recombinant Cynomolgus IL2RA, LEVLFQ tagged Human Cell Fc
    Cynomolgus Monkey IL2RA-618C Recombinant Cynomolgus IL2RA Protein, His-tagged Mammalian Cell His
    Rhesus Macaque IL2RA-2247R Recombinant Rhesus monkey IL2RA Protein, His-tagged Mammalian Cell His
    Canine IL2RA-460C Recombinant Canine IL2RA, His-tagged NS0 His
    Chicken IL2RA-6165C Recombinant Chicken IL2RA Mammalian Cell His
    Cattle IL2RA-1864C Recombinant Cattle IL2RA protein, His & T7-tagged E.coli His/T7
    Pig IL2RA-1866P Recombinant Pig IL2RA protein, His & T7-tagged E.coli His/T7
    CBCRY33 Interleukin-2 with its alpha Receptor E.coli N/A

    il2ra involved in several pathways and played different roles in them. We selected most pathways il2ra participated on our site, such as Cytokine-cytokine receptor interaction, Endocytosis, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with il2ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IFNK; CXCL10; CXCR5; NT5C3; FASLG; Ccl12; IFNG1-2; BMP2; TGFB1; IFNA3
    PIK-Akt signaling pathway THBS2; FLT1; TCL1B4; PKN3; MTOR; ITGB4; DDIT4; FGFR4; GH2; CASP9
    Jak-STAT signaling pathway GH1; STAT5A; EP300; HRASA; RNF207B; MCL1A; CCND3; PIK3R1; IFNA12; AOX1
    Hematopoietic cell lineage CD33; IL6R; CD9; CSF1; Cd24a; IL4R; IL11; TNF; MME; CD22
    HTLV-I infection POLD4; NFATC2; PDGFA; H2-AA; PPP3R1; FZD9; MAP3K3; WNT11; FZD6; PIK3CD

    il2ra has several biochemical functions, for example, drug binding, interleukin-2 binding, interleukin-2 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by il2ra itself. We selected most functions il2ra had, and list some proteins which have the same functions with il2ra. You can find most of the proteins on our site.

    Function Related Protein
    drug binding CHRNB2; SLC6A4A; PDE4D; PPP3CB; PYGB; TLR8; MT2A; HTR2A; FNTB; GABRA1
    interleukin-2 binding IL2RG; IL2RA; IL2RB
    interleukin-2 receptor activity IL2RA; IL2RB

    il2ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with il2ra here. Most of them are supplied by our site. Hope this information will be useful for your research of il2ra.


    Oliveira, PRS; Dessein, H; et al. IL2RA Genetic Variants Reduce IL-2-Dependent Responses and Aggravate Human Cutaneous Leishmaniasis. JOURNAL OF IMMUNOLOGY 194:2664-2672(2015).
    Savilova, AM; Chulkina, MM; et al. Expression of Immunomodulator Gene mRNA in Co-Culture of Mesenchymal Stromal Cells from the Placenta and Human Mononuclear Blood Cells. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 158:561-565(2015).


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