Recombinant Human Alcohol Dehydrogenase 6 (class V), His-tagged

• Cat.No.: ADH6-2405H
• Product Overview: Recombinant humanADH6 protein, fused to His-tag at N-terminus, was expressed in E.coli andpurified by using conventional chromatography

Specification

• Cat. No.: ADH6-2405H
• Description: ADH6, also known asalcohol dehydrogenase 6, is a member of the alcohol dehydrogenase family.Members of this family metabolize a wide variety of substrates, includingethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipidperoxidation products. This protein is expressed in the stomach as well as inthe liver, and it contains a glucocorticoid response element upstream of its5' UTR, which is a steroid hormone receptor binding site
• Form: Liquid. 20mMTris-HCl buffer (pH8.0) containing 30% glycerol, 0.15M NaCl, 1mM DTT
• Molecular Weight: 42.4 kDa (399aa),confirmed by MALDI-TOF
• Purity: > 90% by SDS -PAGE
• Concentration: 0.5mg/ml (determinedby Bradford assay)
• Sequences of aminoacids: MGSSHHHHHHSSGLVPRGSH MGSHMSTTGQ VIRCKAAILW KPGAPFSIEE VEVAPPKAKE VRIKVVATGL CGTEMKVLGSKHLDLLYPTI LGHEGAGIVE SIGEGVSTVK PGDKVITLFL PQCGECTSCL NSEGNFCIQF KQSKTQLMSDGTSRFTCKGK SIYHFGNTST FCEYTVIKEI SVAKIDAVAP LEKVCLISCG FSTGFGAAIN TAKVTPGSTCAVFGLGGVGL SVVMGCKAAG AARIIGVDVN KEKFKKAQEL GATECLNPQD LKKPIQEVLF DMTDAGIDFCFEAIGNLDVL AAALASCNES YGVCVVVGVL PASVQLKISG QLFFSGRSLK GSVFGGWKSR QHIPKLVADYMAEKLNLDPL ITHTLNLDKI NEAVELMKTG KCIRCILLL
• Storage: Can be stored at+4°C short term (1-2 weeks). For long term storage, aliquot and store at-20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: ADH6alcohol dehydrogenase 6 (class V) [ Homo sapiens ]
• Official Symbol: ADH6
• Synonyms: ADH6; alcohol dehydrogenase 6(class V); alcohol dehydrogenase 6; ADH 5; ADH 5; ADH 6; Alcoholdehydrogenase 6 (class V); Alcohol dehydrogenase 6; Aldehyde reductase; ClassV alcohol dehydrogenase 6; UDP GLUCURONOSYLTRANSFERASE 2B10 PRECURSOR,MICROSOMAL; OTTHUMP00000161647; OTTHUMP00000161648; OTTHUMP00000161649;OTTHUMP00000220107; aldehyde reductase; ADH-5
• Gene ID: 130
• mRNA Refseq: NM_001102470
• Protein Refseq: NP_001095940
• MIM: 103735
• Uniprot ID: P28332
• Chromosome Location: 4q23
• Pathway: Biological oxidations,organism-specific biosystem; Drug metabolism - cytochrome P450,organism-specific biosystem; Drug metabolism - cytochrome P450, conservedbiosystem; Ethanol oxidation, organism-specific biosystem; Fatty Acid OmegaOxidation, organism-specific biosystem
• Function: alcohol dehydrogenase (NAD)activity; electron carrier activity; metal ion binding; nucleotide binding;oxidoreductase activity